Coptis, Rhz. – HUANG LIAN

Coptis, Rhz. – HUANG LIAN

Dosis: 10g/Tag Pulver

Das Wesen der Wirkung von Coptis ist die Verbesserung der Zellfunktionen. Dies wirkt sich besonders beim Leberstoffwechsel aus.

Coptis heilt Zivilisationskrankheiten, indem es zum einen die Leber anregt und zum zweiten die Mitochondrien in den Zellen stimuliert. So wird die Bildung und Ablagerung von toxischen Metaboliten vermindert.

Diese Eigenschaften von Coptis machen es zur Behandlung und Vorbeugung des Metabolischen Syndroms (Adipositas, Hypertonie, Insulinresistenz, Hypercholesterinämie) geeignet sowie bei Arteriosklerose, Alzheimer, Krebs, ferner zur Verzögerung des Altersprozesses, der gekennzeichnet ist durch eine Abschwächung der Zellfunktionen und Bildung und Ablagerung von Stoffwechselzwischen- und Endprodukten.

1. Metabolisches Syndrom

1.1.      Diabetes

1.1.1.    Anti-diabetic effect of Coptis Chinensis polysaccharide in high-fat diet with STZ-induced diabetic mice.

Meanwhile, CCPW-1 significantly suppressed the rise in blood glucose after 30 min in OGTT. TG and TC levels of diabetic mice also decreased after CCPW-1 treatment. Furthermore, CCPW-1 showed an obvious antioxidant effect through increasing SOD, CAT activities and decreasing MDA content in pancreas. These results indicate that CCPW-1 could be developed to a potent drug used for the treatment of DM in the future.

1.1.2.    Berberine acutely inhibits the digestion of maltose in the intestine

One-dose preprandial intragastric administration of berberine delayed the rise of post-maltose blood glucose, did not affect postprandial blood glucose after glucose meal, and did not affect the insulin level in normal rats

1.1.3.    Pharmacodyamic material basis of rhizoma coptidis on insulin resistance

Rhizoma Coptidis significantly improved insulin resistance, prevented pre-adipocytes differentiation. Its efficacy may be the synergistic effect of various components. Meanwhile, its role in inhibiting differentiation of pre-adipocytes indicates that coptis to increasing glucose uptake dose not cause fat accumulation and weight increasing

1.1.4.    Pharmacodyamic material basis of rhizoma coptidis on insulin resistance

Rhizoma Coptidis significantly improved insulin resistance, prevented pre-adipocytes differentiation. Its efficacy may be the synergistic effect of various components. Meanwhile, its role in inhibiting differentiation of pre-adipocytes indicates that coptis to increasing glucose uptake dose not cause fat accumulation and weight increasing. This has some clinical significance in the insulin resistance and metabolic syndrome.

1.2.      Hyperlipidämie

1.2.1.    Lipid-lowering effect of berberine in human subjects and rats

The results demonstrate that berberine treatment produced a mild weight loss (average 5 lb/subject) in obese human subjects. But more interestingly, the treatment significantly reduced blood lipid levels (23% decrease of triglyceride and 12.2% decrease of cholesterol levels) in human subjects. Collectively, this study demonstrates that berberine is a potent lipid-lowering compound with a moderate weight loss effect, and may have a possible potential role in osteoporosis treatment/prevention

1.2.2.    Hypocholesterolemia of Rhizoma Coptidis alkaloids is related to the bile acid by up-regulated CYP7A1 in hyperlipidemic rats

The results showed that CAE reduced the levels of serum total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C). CYP7A1 gene expression and its activity was up-regulated dose-dependently accompanying with the increased level of bile acid and the reduced cholesterol level in the livers of the CAE treated hyperlipidemic rats.

1.2.3.    Protective effects of berberine against low-density lipoprotein (LDL) oxidation and oxidized LDL-induced cytotoxicity on endothelial cells

Our results suggest that berberine may protect LDL oxidation and prevent oxLDL-induced cellular dysfunction.

1.3.      Hypertonie

1.3.1.    Effects of Coptis Chinensis on vasoconstrictive activity of isolated thoracic aorta of normoxic and chronic intermittent hypobaric hypoxic rats

Coptis Chinensis significantly decreased NE and KC-induced vasoconstriction of normoxic and CIHH rats‘ isolated aortic rings

2. Aterioskleros

2.1.      Advance of studies on anti-atherosclerosis mechanism of berberine

Coptis Chinensis is a traditional Chinese medicine herb that has the effect of clearing heat and drying dampness, purging fire to eliminate toxin. Berberine is the main alkaloid of Coptis Chinensis, and, recent researches showed that berberine had the effect of anti-atherosclerosis. This paper reviewed the anti-atherosclerosis mechanism of berberine, which may be related to regulating lipids, anti-inflammation, decompression, reducing blood sugar, and inhibiting vascular smooth muscle cell proliferation

3. Krebs

   3.1. Berberine induces apoptosis via the mitochondrial pathway in liver cancer cells.

The present findings demonstrated that berberine induces the apoptosis of Huh7 cells via the mitochondrial pathway.

3.2.      The preventive and curative potential of berberine and coptis on humanhepatocellular carcinoma

Recently, studies from our group reported the hepatoprotective effect of Coptis and its major active component, berberine, on acute liver injury and berberine was extensively studied for their anti-tumor effect. Then we found that berberine (as representative to Coptis) could suppress the angiogenesis of HCC, in which berberine does not directly act on the blood vessel formation, but suppress the expression and secretion of pro-angiogenic factors VEGF in HCC cells

3.3.      In vivo inhibition of S180 tumors by the synergistic effect of the Chinese medicinal herbs Coptis chinensis and Evodia rutaecarpa

The inhibition ratio, ILS and TNF-alpha levels of mice treated with ZJW were 50.54 %, 64.91 % and 1.04 ng/mL, respectively, much higher than HL and WZY when singly used. Furthermore, the activities of acid phosphatase and alkaline phosphatase were significantly increased and the activities of creatine kinase, aldolase and lactate dehydrogenase were reduced in serum, and the expressions of Bax and wild-type p53 proteins were much higher for the mice treated by ZJW compared with HL and WZY single-treatment groups.

3.4.      Coptis extracts enhance the anticancer effect of estrogen receptor antagonists on human breast cancer cells

The results showed that the combined treatment of ER antagonists and the crude extract of coptis or its purified compound berberine conferred synergistic growth inhibitory effect on MCF-7 cells (ER+), but not on MDA-MB-231 cells (ER-).

4. Alzheimer

4.1.      Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer’s disease transgenic mouse model

Our results suggest that BBR provides neuroprotective effects in TgCRND8 mice through regulating APP processing and that further investigation of the BBR for therapeutic use in treating AD is warranted.

4.2.      Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids

These results indicate that Coptidis Rhizoma alkaloids have a strong potential of inhibition and prevention of Alzheimer’s disease (AD) mainly through both ChEs and beta-amyloids pathways, and additionally through antioxidant capacities

5. Colon irritable

5.1.      Analgesic effect of Coptis chinensis rhizomes (Coptidis Rhizoma) extract on rat model of irritable bowel syndrome

These results suggest that CR extract robustly reduces visceral pain that may be mediated via the mechanism of decreasing 5HT release and CCK expression in the distal colon of rats

6. Osteoporose

6.1.      Preventive effects of berberine on glucocorticoid-induced osteoporosis in rats

The present results suggest that berberine prevents glucocorticoid-induced osteoporosis by inhibiting bone resorption and improving bone formation.

7. Gastritis/Ulcus

7.1.      Protective effects and its mechanisms of total alkaloids from rhizoma Coptis chinensis on Helicobacter pylori LPS induced gastric lesion in rats

The findings suggest that TA is a potent protective agent against H. pylori LPS induced gastric mucosal inflammation

7.2.      Study of total alkaloids from Rhizoma Coptis Chinensis on experimental gastric ulcers

TA is a potent candidate in therapeutic drugs for treating gastric ulcer. Its anti-ulcer effective components and mechanism is not only related to Ber and inhibition of gastric acid, but also to other ingredients of TA and mechanism so far unknown

8. Nervenschäden

8.1.      Protective effects and mechanism of total coptis alkaloids on a beta 25-35 induced learning and memory dysfunction in rats

TCA could improve A beta 25-35 induced dysfunction of learning and memory in rats, and its protective mechanism is associated with its actions in decreasing MDA level, increasing Mn-SOD activity and inhibiting the expression of NF-kappa B in cerebral cortex       

 

TCM

Ein Vergleich des Wirkspektrums von Rhz. Coptidis, wie er sich durch die Analyse wissenschaftlicher Studien ergibt, und Benskys TCM-Pharmakopoe ergibt grosse Unterschiede:
Coptis erscheint laut TCM-Quellen allein als Mittel bei hitzigen Infektionskrankheiten.
Die Wirkung auf innere Krankheiten wie dem metabolischen Syndrom oder Krebs bleibt fast ganz aussen vor.
Die 5-Elementeanalyse bildet die Energiedynamik von Rhz. Coptidis wie folgt ab:
Blau bedeutet :  TCM-Quellen
Grün bedeutet:  TCM-Quellen und Studien
Schwarz :            Studien
Rot:                       Studien Hauptwirkung

Zum Verständnis der Abkürzungen des Schaubildes siehe

Struktur – und Wandlungsmodell der chinesischen Medizin
http://www.chinesischemedizin.com/CMS/index.php/struktur-und-wandlungsmodell.html