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Chinesische Heilkräuter, Curcuma, Rhz.

Curcuma, Rhz. – JIANG HUANG


Curcuma, Rhz. – JIANG HUANG

Dosis: 3-9 g/Tag

Curcuma ist ein bedeutendes Mittel zur Bekämpfung von Schleim. In Gebieten, in denen ein hoher Konsum von Curcuma traditionell ist, sind Schleimkrankheiten wie Alzheimer, Arteriosklerose oder Rheuma unbekannt. Als Blutstaumittel wirkt Curcuma gut bei Dysmenorrhoe und allgemein Schmerzen. Es regt die Verdauungsdrüsen an und fördert so insbesondere die Fettverdauung.

  1.    Arthrose

Strong molecular evidence has been published for its potency to target multiple inflammatory diseases. However, naturally occurring curcumin cannot achieve its optimum therapeutic outcomes due to its low solubility and poor bioavailability. Nevertheless, curcumin presents great potential for treating OA and has been categorized as having preclinical evidence of efficacy.

At 8 weeks after treatment initiation, knee pain VAS scores were significantly lower in the Theracurmin group than in the placebo group

  1. domestica extracts are as effective as ibuprofen for the treatment of knee osteoarthritis. The side effect profile was similar but with fewer gastrointestinal AE reports in the C. domestica extracts group.
  1.   Candida

An antifungal mechanism of curcumin lies in membrane-targeted action within Candida albicans.

Therefore, this study suggests that curcumin exerts antifungal activity via inducing disruption of fungal plasma membrane

  1.    Krebs

This study revealed the promising therapeutic role of curcumin against hepatocellular carcinoma owing to its antiangiogenic, antiproliferative, and apoptotic effects

Therefore, curcumin and quercetin, if given in combination shall exhibit enhanced chemopreventive potential against development of lung carcinogenesis by stimulating the apoptotic machinery

Here we report that bCSCs are endowed with aggravated migration property due to the inherent suppression of the tumor suppressor, E-cadherin, which is restored by curcumin

In this review, we summarize the understanding of chemopreventive effects of curcumin in the prevention of cancer via the regulation of various cell signaling and genetic pathways.

  1.   Entzündung

Oral Administration of Nano-Emulsion Curcumin in Mice Suppresses Inflammatory-Induced NFκB Signaling and Macrophage Migration.

These data demonstrate that curcumin can suppress inflammation by inhibiting macrophage migration via NFκB and MCP-1 inhibition and establish that NEC is an effective therapeutic formulation to increase the bioavailability of curcumin in order to facilitate this response.

  1.    Mastitis

Effectiveness of topical curcumin for treatment of mastitis in breastfeeding women: a randomized, double-blind, placebo-controlled clinical trial.

The results of the current study indicate that topical preparation of curcumin successfully decrease the markers of lactational mastitis such as pain, breast tension and erythema within 72 hours of administration without side effects. Thus, topical preparation of curcumin could be safely administered for those suffering from lactational mastitis after excluding infectious etiologies.

  1.    Metabolisches Syndrom

Co-administration of Black seeds and Turmeric shows enhanced efficacy in preventing metabolic syndrome in fructose-fed rats

At 6 weeks, the co-administration of both herbs, at half the doses of individual herbs, was the most effective (p<0.001) in preventing hypertension, hyperglycemia, dyslipidemia, hyperinsulinemia and endothelial dysfunction than the individual herbs

6.1. Diabetes

Resveratrol and curcumin enhance pancreatic β-cell function by inhibiting phosphodiesterase activity

Collectively, we demonstrate a novel role for natural-occurring polyphenols as PDE inhibitors that enhance pancreatic β-cell function.

6.2.  Hypertonie

Curcumin protects against cadmium-induced vascular dysfunction, hypertension and tissue cadmium accumulation in mice.

These findings suggest that curcumin, due to its antioxidant and chelating properties, is a promising protective agent against hypertension and vascular dysfunction induced by Cd

6.3. Hyperlipidämie

Oral Supplementation with Non-Absorbable Antibiotics or Curcumin Attenuates Western Diet-Induced Atherosclerosis and Glucose Intolerance in LDLR-/- Mice – Role of Intestinal Permeability and Macrophage Activation.

Consequently, both these interventions significantly reduced WD-induced glucose intolerance and atherosclerosis in LDLR-/- mice. These studies not only establish the important role of intestinal barrier function, but also identify oral supplementation with curcumin as a potential therapeutic strategy to improve intestinal barrier function and prevent the development of metabolic diseases.

  1.    Wahrnehmung und Stimmung

Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population.

A significant acute-on-chronic treatment effect on alertness and contentedness was also observed. Curcumin was associated with significantly reduced total and LDL cholesterol and had no effect on hematological safety measures.

  1.    Wundheilung

Curcumin is a naturally derived substance with innate antimicrobial and wound healing properties. Acting by multiple mechanisms, curcumin is less likely than current antibiotics to select for resistant bacteria.

The recent literature on the wound healing properties of curcumin also provides evidence for its ability to enhance granulation tissue formation, collagen deposition, tissue remodeling and wound contraction.

  1.    Psoriasis

Curcumin inhibits imiquimod-induced psoriasis-like inflammation by inhibiting IL-1beta and IL-6 production in mice

In conclusion, curcumin can relieve the IMQ-induced psoriasis-like inflammation in a mouse model, similar to the effects of clobetasol. Therefore, we have every reason to expect that curcumin will be used in the treatment of psoriasis in the future.

  1.   Arteriosklerose

Consequently, both these interventions significantly reduced WD-induced glucose intolerance and atherosclerosis in LDLR-/- mice. These studies not only establish the important role of intestinal barrier function, but also identify oral supplementation with curcumin as a potential therapeutic strategy to improve intestinal barrier function and prevent the development of metabolic diseases.

Curcumin through a series of complex mechanisms, alleviated the adverse effects of high fat diet on weight gain, fatty liver development, dyslipidemia, expression of inflammatory cytokines and atherosclerosis in Ldlr(-/-) mouse model of human atherosclerosis. One of the mechanisms by which low dose curcumin modulates atherogenesis is through suppression of aP2 and CD36 expression in macrophages, which are the key players in atherogenesis.

  1. Alzheimer

As a result, compounds with multiple cellular targets such as curcumin become the subject of intense research works. As mentioned in the review, curcumin could modulate multiple signaling pathways involved in virtually most neurodegenerative diseases and effectively treat neurodegenerative diseases as an improved therapeutic modality.

Due to various effects of curcumin, such as decreased Beta-amyloid plaques, delayed degradation of neurons, metal-chelation, anti-inflammatory, antioxidant and decreased microglia formation, the overall memory in patients with AD has improved.

  1. Morbus Crohn

Curcumin therapy in inflammatory bowel disease: a pilot study

A pure curcumin preparation was administered in an open label study to five patients with ulcerative proctitis and five with Crohn’s disease. All proctitis patients improved, with reductions in concomitant medications in four, and four of five Crohn’s disease patients had lowered CDAI scores and sedimentation rates.


  1. Alterung

Dietary Intake of Curcuma longa and Emblica officinalis Increases Life Span in Drosophila melanogaster

The results revealed significant increase in life span of Drosophila flies on exposure to both the plant products, more efficiently by C. Longa than by E. officinalis. In order to understand whether the increase in lifespan was due to high-antioxidant properties of these medicinal plants, we performed enzymatic assays to assess the SOD and catalase activities in case of both treated and control Drosophila flies.

  1. Hepatoprotection, Cholelithiasis, and Cholestasis

Hepatoprotection, Cholelithiasis, and Cholestasis

Turmeric’s hepatoprotective effects, evidenced in a number of animal studies, suggest it may be used in cases of toxic insult due to exogenous toxins from lifestyle and environmental exposures. Curcumin has choleretic activity that increases bile output and solubility, which may be helpful in treating gallstones.


  1. Magengeschwür

Gastric Ulcer

An open, phase II trial was performed on 25 patients with endoscopically-diagnosed gastric ulcer. Participants were given 600 mg powdered turmeric five times daily. After four weeks, ulcers had completely healed in 48 percent of patients. The success rate increased over time, with 76 percent being ulcer free after 12 weeks of treatment. No significant adverse reactions or blood abnormalities were noted.

  1. Uveitis

Chronic Anterior Uveitis

Thirty-two patients with chronic anterior uveitis took 375 mg curcumin three times daily for 12 weeks. Curcumin was effective in 86 percent of individuals, and was as effective as corticosteroid therapy, the only available standard treatment.

  1. KHK

Polyphenols: benefits to the cardiovascular system in health and in aging.

Polyphenols such as resveratrol, epigallocatechin gallate (EGCG), and curcumin have been acknowledged for having beneficial effects on cardiovascular health, while some have also been shown to be protective in aging.

  1. Ödeme

Analgesic and Diuretic Activity of Curcuma xanthorrhiza

The diuretic effect of the extract started after 1 h at doses of 150 and 300 mg/kg body weight of mice. It was observed that the diuretic activity increased with increasing the concentration of the test sample








Die 5-Elementeanalyse bildet die Energiedynamik von Trigonella wie folgt ab:

Blau bedeutet :  TCM-Quellen
Grün bedeutet:  TCM-Quellen und Studien
Schwarz :            Studien
Rot:                      Studien Hauptwirkung

Struktur – und Wandlungsmodell der chinesischen Medizin





Ein Gedanke zu “Curcuma, Rhz. – JIANG HUANG

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