Ampelopsis, Rd. – BAI LIAN – Scheinrebe

Ampelopsis, Rd. – BAI LIAN – Scheinrebe

Dosis: 20-80g g/Tag

Die Scheinrebe löst Feuchtigkeitsstau im Gewebe auf und vertreibt eingedrungene äußere Feuchte Kälte. Es handelt sich um ein Bindegewebsmittel, welches schlaffes Gewebe stärkt und Fibrosen erweicht und auflöst.

1. Entzündungen

Suppression of Inflammatory Responses by Dihydromyricetin, a Flavonoid from Ampelopsis grossedentata, via Inhibiting the Activation of NF-κB and MAPK Signaling Pathways

Taken together, the present results suggest that 1 exerts its topical anti-inflammatory action through suppressing the activation of NF-κB and the phosphorylation of p38 and JNK. Thus, 1 may be a potentially useful therapeutic agent for inflammatory-related diseases.

2.       Verbrennungen und Verbrühungen

Effect of Ampelopsis Radix on wound healing in scalded rats

These results suggest that AJE possesses scald wound healing activity via accelerating the scald wound repair during the inflammation and proliferative phases of the healing process.

3.        Krebs

• Characterization and antitumor activities of a water-soluble polysaccharide from Ampelopsis megalophylla

These results suggest that AMP had clear antitumor activity, which might be related to its regulation of immune function in mice.

• Dihydromyricetin induces apoptosis and inhibits proliferation in hepatocellular carcinoma cells

DHM exhibited no cytotoxicity to normal human hepatic cell lines. Furthermore, it was found that DHM induced cell apoptosis in a p53-dependent manner. DHM upregulated p53 expression, and the upregulation of p53 increased the levels of the cleaved caspase-3 protein, directly inducing cell apoptosis. These results indicate that DHM is a promising candidate for the treatment of HCC.

• Ampelopsin induces cell growth inhibition and apoptosis in breast cancer cells through ROS generation and endoplasmic reticulum stress pathway

Taken together, these results demonstrate that AMP has anti-tumor effects against breast cancer cells through ROS generation and ER stress pathway, which therefore provide experimental evidences for developing AMP as a new therapeutic drug for breast cancer.

• cantoniensis inhibits the proliferation of murine leukemia WEHI-3 cells in vivo and promotes immunoresponses in vivo.

It was found that the NK cells from mice after treatment with AC can kill the YAC-1 target cells. Therefore, the AC treatment increased NK cell activity. In conclusion, AC can affect WEHI-3 cells in vivo and promote macrophage and NK cell activities.

4.        Fettleber

Dihydromyricetin improves glucose and lipid metabolism and exerts anti-inflammatory effects in nonalcoholic fatty liver disease: A randomized controlled trial.

We conclude that dihydromyricetin supplementation improves glucose and lipid metabolism as well as various biochemical parameters in patients with nonalcoholic fatty liver disease, and the therapeutic effects of dihydromyricetin are likely attributable to improved insulin resistance and decreases in the serum levels of tumor necrosis factor-alpha, cytokeratin-18, and fibroblast growth factor 21.

5.       Osteoporose

Ampelopsis brevipedunculata extract prevents bone loss by inhibiting osteoclastogenesis in vitro and in vivo

These results demonstrate that ABE prevents LPS-induced bone erosion through inhibition of osteoclast differentiation and function, suggesting the promise of ABE as a potential cure for various osteoclast-associated bone diseases.

6.      Parkinson

Ampelopsis Radix Protects Dopaminergic Neurons against 1-Methyl-4-phenylpyridinium/1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Toxicity in Parkinson’s Disease Models In Vitro and In Vivo

In the mouse PD model, AJW protected the dopaminergic neurons in the brain, leading to motor improvements. AJW inhibited the MPTP-evoked accumulation of 8-hydroxydeoxyguanosine in the brain. These data suggest that AJW has neuroprotective effects with antioxidant mechanisms in PD models.

 

7. Hepatitis

Ethanol Extract from Ampelopsis sinica Root Exerts Anti-Hepatitis B Virus Activity via Inhibition of p53 Pathway In Vitro.

The results showed that EASR selectively inhibited the activities of HBV promoters (Cp, S1p and Fp) and the p53 signaling pathway in HepG2 cells significantly. These data indicate that EASR exerts anti-HBV effects via inhibition of HBV promoters and the p53-associated signaling pathway, which helps to elucidate the mechanism underlying the potential therapeutic value of EASR.

 

8.       Diabetes

Experimental studies of hypoglycemic action on total flavone of Ampelopsis grossedentata from Guangxi

GXTF had better therapeutical action on diabetes mice induced by alloxan, and could significantly lowered the blood glucose levels of hyperglycemic mice induced by epinephrine and glucose, but had no significant effects on blood glucose levels of normal mice.

9.     Bindegewebsschwäche

Ampelopsis brevipedunculata (Vitaceae) extract stimulates collagen synthesis through superoxide generation in the serum-free cultures of rat dermal fibroblasts and Ito cells

Stimulation of collagen synthesis was caused by superoxide because addition of superoxide dismutase but not pyruvate, an antioxidant of hydrogen peroxide, or dimethyl sulfoxide, an antioxidant of the hydroxyl radical, abrogated the stimulatory effect. The extract may arrest the progress of liver injury mediated by oxygen free radicals generated in the presence of ferrous iron.

10.        Dupuytren

La vigne vierge constitue un grand remède des arthrites inflammatoires déformantes (polyarthrites rhumatoïdes, rhumatismes inflammatoires), des grandes déformations de la P.C.E. et plus particulièrement des douleurs et déformations des petites articulations.

Elle s’indique tout particulièrement lorsque les tendons et les ligaments sont en cause.

La vigne vierge agit efficacement sur la rétraction scléreuse et est indiquée dans diverses maladies (Dupuytren, Peyronie, nodule de Bouchard, nodule de Heberden).

Plante de nature Yin, antiscléreuse, elle s’indique dans les indurations locales fibreuses, en particulier dans les séquelles inflammatoires, notamment les adhérences post-inflammatoires.
http://www.feh.be/fsu_ampelopsis.htm

Ampelopsis Weitchii stimulates the regeneration of joints, cartilage, and ligaments and poorly healed inflammatory conditions, which can eventually become chronic, but not malignant. This remedy is indicated for conditions such as non-inflammatory irritations of the conjunctivitis and aponeurosis, as well as chronic rheumatism, rheumatoid arthritis, Dupuytren’s disease, ankylosing spondylitis and cartilage regeneration.

http://www.forresthealth.com/ampelopsis-weitchii-gemmotherapy.html

11. Irisinmangel

Dihydromyricetin improves skeletal muscle insulin resistance by inducing autophagy via the AMPK signaling pathway

DHM improved SMIR by inducing autophagy via the activation of AMPK signaling pathway.

12. Alzheimer

Dihydromyricetin ameliorates behavioral deficits and reverses neuropathology of transgenic mouse models of Alzheimer’s disease.

These results suggest that DHM treatment not only improves symptoms, but also reverses progressive neuropathology of mouse models of AD including reducing Aβ peptides, while restoring gephyrin levels, GABAergic transmission and functional synapses. Therefore DHM is a promising candidate medication for AD. We propose a novel target, gephyrin, for treatment of AD.

13.     Alkoholvergiftung

Dihydromyricetin as a novel anti-alcohol intoxication medication.

In summary, we determined DHM anti-alcoholic effects on animal models and determined a major molecular target and cellular mechanism of DHM for counteracting alcohol intoxication and dependence. We demonstrated pharmacological properties of DHM consistent with those expected to underlie successful medical treatment of AUDs; therefore DHM is a therapeutic candidate.

14.     Hyperlipidämie

Regulation of plasma lipids and blood glucose

The intragastric administration of Ampelsis grossedentata reduces the levels of serum total cholesterol (TC) and triglyceride (TG), and increases serum high-density lipoprotein cholesterol (HDL-C) levels in rats, indicating a hypocholesterolemic effect of ampelopsin

15. Hypertonie

Anti-hypertension effect

These findings suggest that ampelopsin may function as an anti-hypertension drug by selectively blocking voltage-dependent calcium channels (PDC).

16.     Diabetes

Experimental studies of hypoglycemic action on total flavone of Ampelopsis grossedentata from Guangxi

GXTF had better therapeutical action on diabetes mice induced by alloxan, and could significantly lowered the blood glucose levels of hyperglycemic mice induced by epinephrine and glucose, but had no significant effects on blood glucose levels of normal mice. Acute toxicity test showed that the maximum oral dosage is 26.0 g.kg-1. CONCLUSION: GXTF has better hypoglycemic effect on many strain animal models and toxicity is vary small.

17. Aphten

Effects of dihydromyricetin on tumor necrosis factor and NF-kappaB p65 of RAU rats

It is considered that DMY could inhibited occurrence of oral mucosa ulcer in RAU rats. One principle of it’s effects could be that DMY controlled NF-kappaB p65 regulation on transcription and release of TNF-alpha mRNA in macrophages in oral mucosa ulcer tissue and lead to fall of TNF-alpha content in oral mucosa tissue causing role of anti-oral mucosa ulcer.

Info:

100 g des getrockneten Krauts enthält 25.2 g Ampelopsin

 

Wirkungen:

DHM treatment significant increased serum Irisin levels in humans and rats.

DHM, as a potent exercise mimetic, is expected to benefit patients suffering from metabolic diseases.

Dihydromyricetin an active ingredient against cellulite because it affects the storage of fat in fat cells anti-bacterial, anti-cancer, antioxidant, hepatoprotective and anti-hypertension
Artikel

http://www.sciencedirect.com/science/article/pii/S221345301200002X

 

TCM

 

Die 5-Elementeanalyse bildet die Energiedynamik von Rd. Ampelopsis wie folgt ab:

Blau bedeutet :  TCM-Quellen
Grün bedeutet:  TCM-Quellen und Studien
Schwarz :            Studien
Rot:                      Studien Hauptwirkung

Zum Verständnis der Abkürzungen des Schaubildes siehe

Struktur – und Wandlungsmodell der chinesischen Medizin
http://www.chinesischemedizin.com/CMS/index.php/struktur-und-wandlungsmodell.html