Uncaria – Gou Teng – Indischer Morgenstern

Uncaria – Gou Teng – Indischer Morgenstern

Dosis: 5-20g/Tag
Uncaria wirkt bei innerer oder äußerer Leberhitze- oder wind. Es beruhigt Krämpfe, innere Unruhe, Hypertonie und Schlaflosigkeit. Darüber hinaus wirkt es bei Schleim, der durch Wind und Hitze entstand, insbesondere bei Nervenschleim in Form von Alzheimer, Parkinson, Demenz oder Arteriosklerose.

1.     Arthrose

• UP3005, a Botanical Composition Containing Two Standardized Extracts of Uncaria gambir and Morus alba, Improves Pain Sensitivity and Cartilage Degradations in Monosodium Iodoacetate-Induced Rat OA Disease Model

UP3005 resulted in almost a complete inhibition in proteoglycans degradation, reductions of 16.6% (week 4), 40.5% (week 5), and 22.0% (week 6) in pain sensitivity, statistically significant improvements in articular cartilage matrix integrity, minimal visual subchondral bone damage, and statistically significant increase in bone mineral density when compared to the vehicle control with MIA.

• Effect of a Herbal-Leucine mix on the IL-1β-induced cartilage degradation and inflammatory gene expression in human chondrocytes

Our data suggests that HLM could be chondroprotective and anti-inflammatory agent in arthritis, switching chondrocyte gene expression from catabolic direction towards anabolic and regenerative, and consequently this approach may be potentially useful as a new adjunct therapeutic/preventive agent for OA or injury recovery.

 

2.    Stomatitis

• Uncaria tomentosa Gel against Denture Stomatitis: Clinical Report.

After 1 week of this treatment, she had significantly reduced signs of the disease. Despite the existence of a great number of antifungal agents, treatment failure is observed frequently.

• Evaluation of different treatment methods against denture stomatitis: a randomized clinical study.

U tomentosa gel is an effective topical adjuvant treatment for denture stomatitis.

 

3.    Krebs

3.1. Brustkrebs

Selective anticancer activity of hirsutine against HER2‑positive breast cancer cells by inducing DNA damage.

Considering that there was no difference between MDA-MB-453 and MCF-7 cells in regards to irinotecan‑induced DNA damage response, our present results indicate the selective anticancer activity of hirsutine in HER2-positive breast cancer by inducing a DNA damage response.

3.2. Blasenkrebs

Quinovic acid glycosides purified fraction from Uncaria tomentosa induces cell death by apoptosis in the T24 human bladder cancer cell line.

In conclusion, we demonstrated that QAPF of U.tomentosa has a potent inhibitory effect on the growth of human bladder cancer cell lines by inducing apoptosis through modulation of NF-κB, and we suggest that QAPF may become a potential therapeutic agent for the prevention and/or treatment of this cancer.

3.3. Darmkrebs

Methanolic extracts of Uncaria rhynchophylla induce cytotoxicity and apoptosis in HT-29 human colon carcinoma cells.

These results indicate that URE contains bioactive materials with strong activity, and is a potential chemotherapeutic agent candidate against HT-29 human colon carcinoma cells.

3.4. Leukämie

Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells.

Our results show the strong apoptotic effects of pteropodine and uncarine F on acute leukaemic lymphoblasts and recommend the alkaloids for further studies in xenograft models.

4.    Bindegewebsschwäche

Antiaging agent

This invention relates to an anti-aging agent, more particularly, it relates to an anti-aging agent having an elastase inhibiting action and capable of maintaining the tautness and elasticity of the skin and maintaining a youthful state of the skin.

5.   Alterung

• Antiaging agent

This invention relates to an anti-aging agent, more particularly, it relates to an anti-aging agent having an elastase inhibiting action and capable of maintaining the tautness and elasticity of the skin and maintaining a youthful state of the skin.

• CYTOPROTECTIVE EFFECT ON OXIDATIVE STRESS AND INHIBITORY EFFECT ON CELLULAR AGING OF UNCARIA SINENSIS HAVIL

The ethanol extract from the hooks and stems of Uncaria sinensis Havil (Rubiaceae) exhibited significant inhibitory activity on oxidative stress and the age-dependent shortening of the telomeric DNA length.

• Quinic Acid Could Be a Potential Rejuvenating Natural Compound by Improving Survival of Caenorhabditis elegans under Deleterious Conditions

Here we report that QA can provide protection in Caenorhabidits elegans and improve worm survival under stress. Under heat stress and oxidative stress, QA-treated wild-type C. elegans N2 (N2) survived 17.8% and 29.7% longer, respectively, than the control worms. Our data suggest that under heat stress, QA can upregulate the expression of the small heat shock protein hsp-16.2 gene, which could help the worms survive a longer time. We also found that QA extended the C. elegans mutant VC475 [hsp-16.2 (gk249)] life span by 15.7% under normal culture conditions.

6.    Neurodegeneration

6.1. Alzheimer

• MONOAMINE OXIDASE B (MAO-B) INHIBITION BY ACTIVE PRINCIPLES FROM UNCARIA RHYNCHOPHYLLA

This suggests that these two compounds, isolated here for the first time from Uncaria rhynchophylla, might be able to protect against neurodegeneration in vitro, and, therefore, the molecular mechanism deserves further study.

• Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer’s beta-amyloid proteins.

Our results suggest that Uncaria rhynchophylla has remarkably inhibitory effects on the regulation of Abeta fibrils, and we conclude that this medicinal herb could have the potency to be a novel therapeutic agent to prevent and/or cure AD.

6.2. Gedächtnisschwäche

Isorhynchophylline improves learning and memory impairments induced by D-galactose in mice

Our results amply demonstrated that IRN was able to ameliorate cognitive deficits induced by D-gal in mice, and the observed cognition-improving action may be mediated, at least in part, through enhancing the antioxidant status and anti-inflammatory effect of brain tissues via NFκB signaling.

6.3. Parkinson

MONOAMINE OXIDASE B (MAO-B) INHIBITION BY ACTIVE PRINCIPLES FROM UNCARIA RHYNCHOPHYLLA

This suggests that these two compounds, isolated here for the first time from Uncaria rhynchophylla, might be able to protect against neurodegeneration in vitro, and, therefore, the molecular mechanism deserves further study.

6.4. Demenz

Kampo formulations, chotosan, and yokukansan, for dementia therapy: existing clinical and preclinical evidence.

These studies have led not only to the concept of a neuronal basis for the CTS- and YKS-induced amelioration of cognitive function and emotional/psychiatric symptom-related behavior in animal models, but also to a proposal that ingredient(s) of Uncariae Uncis cum Ramulus, a medicinal herb included in CTS and YKS, may play an important role in the actions of these formulae in dementia patients.

7.    Hypertonie

ANTIHYPERTENSIVE AND NEUROPROTECTIVE ACTIVITIES OF RHYNCHOPHYLLINE: THE ROLE OF RHYNCHOPHYLLINE IN NEUROTRANSMISSION AND ION CHANNEL ACTIVITY

Rhynchophylline mainly acts on cardiovascular and central nervous system diseases, including hypertension, bradycardia, arrhythmia, sedation, vascular dementia, epileptic seizures, drug addiction, and cerebral ischemia.

8.   Depressionen

Antidepressant-Like Activity of the Ethanolic Extract from Uncaria lanosa Wallich var. appendiculata Ridsd in the Forced Swimming Test and in the Tail Suspension Test in Mice.

Our findings support the view that UL(EtOH) exerts antidepressant-like activity. The antidepressant-like mechanism of UL(EtOH) may be related to the increase in monoamines levels in the hippocampus, cortex, striatum, and hypothalamus of mice.

9.    Epilepsie

Uncaria rhynchophylla and rhynchophylline improved kainic acid-induced epileptic seizures via IL-1β and brain-derived neurotrophic factor.

Our findings suggested that UR and RP exhibited anti-convulsive effects in KA-induced rats via the regulation of TLR and neurotrophin signaling pathways, and the subsequent inhibition of IL-1β and BDNF gene expressions.

10.    Herpes

Antimutagenic and antiherpetic activities of different preparations from Uncaria tomentosa (cat’s claw).

The antiherpetic activity from the samples under investigation seemed to be associated with the presence of polyphenols or their synergistic effect with oxindole alkaloids or quinovic acid glycosides, once both purified fractions did not present activity when evaluated alone. Inhibition of viral attachment in the host cells was the main mechanism of antiviral activity.

11. Verhütung

Contraceptive effect of Uncaria tomentosa (cat’s claw) in rats with experimental endometriosis.

The findings suggest that Uncaria tomentosa has contraceptive effect.

12. Neurodermitis

Oral administration of Uncariae rhynchophylla inhibits the development of DNFB-induced atopic dermatitis-like skin lesions via IFN-gamma down-regulation in NC/Nga mice.

Oral administration of UR to DNFB-treated NC/Nga mice was found to inhibit ear thickness increases and the skin lesions induced by DNFB. IFN-gamma production by CD4+ T cells from the lymph nodes of DNFB-treated NC/Nga mice was significantly inhibited by UR treatment

13. Entzündung

A water soluble extract from Uncaria tomentosa (Cat’s Claw) is a potent enhancer of DNA repair in primary organ cultures of human skin.

The data clearly demonstrated that co-incubation with C-Med-100 reduced skin cell death from UV exposure, and this protection was accounted for by a concomitant increase in DNA repair. Based on these results, it was concluded that C-Med-100 was a natural plant extract worthy of further consideration as a sunscreen product.

14. Hautschäden durch UV

A water soluble extract from Uncaria tomentosa (Cat’s Claw) is a potent enhancer of DNA repair in primary organ cultures of human skin.

The data clearly demonstrated that co-incubation with C-Med-100 reduced skin cell death from UV exposure, and this protection was accounted for by a concomitant increase in DNA repair. Based on these results, it was concluded that C-Med-100 was a natural plant extract worthy of further consideration as a sunscreen product.

15. Arteriosklerose

Uncaria rhynchophylla induces angiogenesis in vitro and in vivo.

The angiogenic activity of Uncaria rhynchophylla was confirmed using an in vivo Matrigel angiogenesis model, showing promotion of blood vessel formation. These results suggest that Uncaria rhynchophylla could potentially used to accelerate vascular wound healing or to promote the growth of collateral blood vessel in ischemic tissues.

Monographien

http://dog2doc.com/Alt_med/library/monograph/catsclaw.html

 

Artikel

http://www.life-enthusiast.com/cats-claw-a-5197.html

http://www.herbwisdom.com/herb-cats-claw.html

http://treelite.com/articles/articles/cats-claw-%28uncaria-tomentosa%29-.html

TCM

Die 5-Elementeanalyse bildet die Energiedynamik von Uncaria wie folgt ab:

Blau bedeutet :  TCM-Quellen
Grün bedeutet:  TCM-Quellen und Studien
Schwarz :            Studien
Rot:                       Studien Hauptwirkung

Zum Verständnis der Abkürzungen des Schaubildes siehe

Struktur – und Wandlungsmodell der chinesischen Medizin
http://www.chinesischemedizin.com/CMS/index.php/struktur-und-wandlungsmodell.html