Pfaffia paniculata – Brasilianischer Ginseng
Pfaffia ist ein großes Tonikum für die Nierenenergie. Es stärkt die allgemeine Fähigkeit, sich mit krankmachenden Einflüssen auseinanderzusetzen, insbesondere die Streßresistenz und das Immunsystem.
Es enthält sehr viel Ecdystone, einen Stoff, welcher die Sexualhormonproduktion anregt und zwar sowohl Östogern wie Testosteron. Es wird besonders bei Sportlern zum Muskelaufbau eingesetzt, ferner bei PMS, im Klimakterium, Impotenz und Libidomangel.
In conclusion, this study demonstrates the beneficial effects, in-vitro, of PP extract on the RBC deformability of SCD patients, notably at high shear stress (a shear stress condition usually found in capillaries).
Treatment with the 200mg/kg dose on the curative schedule was able to reduce the MDS and the EL. In addition, MPO activity was reduced, GSH levels were maintained, and the levels of pro-inflammatory cytokines and CRP were decreased. In conclusion, the protective effect of P. paniculata was related to reduced oxidative stress and CRP colonic levels, and due to immunomodulatory activity as evidenced by reduced levels of IL-1β, INF-γ, TNF-α and IL-6.
- Inhibitory effects of Pfaffia paniculata (Brazilian ginseng) on preneoplastic and neoplastic lesions in a mouse hepatocarcinogenesis model.
Preneoplastic or neoplastic lesions were measured, quantified and classified morphologically. The treatment reduced the incidence, mean area and number of lesions, indicating an inhibitory effect of these roots on hepatocarcinogenesis promotion or progression steps.
- Cytotoxic effects of butanolic extract from Pfaffia paniculata (Brazilian ginseng) on cultured human breast cancer cell line MCF-7
Butanolic extract of the roots of P. paniculata showed cytotoxic effect MCF-7 cell line, as determined with crystal violet assay, cellular death with acridine orange/ethidium bromide staining, and cell proliferation with immunocytochemistry of bromodeoxyuridine (BrdU).
- Pfaffia paniculata-induced changes in plasma estradiol-17beta, progesterone and testosterone levels in mice
Regarding changes in plasma concentrations of hormones, levels of the sex hormones estradiol-17beta, progesterone and testosterone were clearly higher for mice that drank P. paniculata root-enriched water than for mice that drank plain water.
- Stimulating property of Turnera diffusa and Pfaffia paniculata extracts on the sexual-behavior of male rats
The highest dose of either extract (1 ml/kg) (as well as the combination of 0.5 ml/kg of each extract) increased the percentage of rats achieving ejaculation and significantly reduced mount, intromission and ejaculation latencies, post-ejaculatory interval and intercopulatory interval. Neither extract affected locomotor activity.
Our results suggest that inhibition of glutamatergic metabotropic receptors and TNF-alpha may account for the antinociceptive action reported for the HE in models of chemical pain used in this study.
The results indicated that stimulation of endogenous production of nitric oxide, followed by soluble guanylate cyclase activation, was implicated in the anti-oedematogenic action of HEPG.
Oral administration of 100 mg/kg of PE and 0.5 mg/kg of dexamethazone inhibited by 29 and 61%, the granulomatous tissue formation (p>0.05), respectively. These results indicate the potential of this plant extract to treat chronic inflammation.
With the chronic treatment, a relevant decrease of the number of sessions necessary for learning in the group of old mice treated with the extract was evident. A partial reversal of the memory de fi cit induced by age in the old mice treated with the extract was found in the passive avoidance test. The results suggest that the standardized extract from Pfaffia glomerata roots promoted an increase in both learning and memory of old mice treated in the chronic test.
In conclusion, AEP effectively protected the gastric mucosa and inhibited gastric acid secretion in rats, probably by involving the histaminergic pathway and an enhanced production of nitric oxide in the stomach.
Orally, suma is used as an immune enhancer or adaptogen to help the body adapt to stress by enhancing or restoring the immune system. Suma is also used orally for cancer, diabetes, tumors, as a tonic to restore body function, as an aphrodisiac, and to improve male sexual performance. Topically, suma is used for wounds and skin problems.
Adaptogen, analgesic (pain relief), anemia, anti-inflammatory, anxiety, appetite stimulant, arthritis, blood circulation, blood disorders (sickle cell), bronchitis, cancer, chronic fatigue syndrome, diabetes, digestion, high blood pressure, high cholesterol, hormonal disorders, hyperglycemia (high blood sugar levels), immune enhancement, increased muscle mass, leukemia, libido (sexual desire), memory enhancement, menopause, premenstrual syndrome, rheumatoid arthritis, sexual dysfunction, stress, tonic, ulcers.
Suma is used as a tonic for the cardiovascular system, the central nervous system, the reproductive system, and the digestive system. It is an effective treatment for hormonal disorders and symptoms of menopause because of two hormones, sitosterol and stigmasterol. Additionally, it is helpful in the treatment of sexual dysfunction, infertility, and sterility. It has been used to restore nerve and glandular functions and to balance the endocrine system. As an immunostimulant, it is used to treat exhaustion caused by Epstein-Barr disease and Chronic Fatigue System. Hypoglycemia, mononucleosis, high blood pressure, and stress are also treated with Suma Root. Due to its anabolic agent, beta-ecdysterone, and three ecdysteroid glycosides contained in Suma Root, Russian Olympic athletes used the herb to increase muscle-building and endurance without the side affects associated with steroids. In addition, Suma Root has been used for arteriosclerosis, diabetes, rheumatism, and bronchitis.
- AnalgesicsAnalgesics: Based on preliminary study, Pfaffia paniculata root may have analgesic effects (6).
- AntibioticsAntibiotics: Based on secondary sources, suma root may contain up to 11% saponins, which may be responsible for its potential antibacterial effects. The effects of suma with antibacterial agents are not well understood.
- Anti-inflammatory agentsAnti-inflammatory agents: Based on preliminary and animal study, Pfaffia paniculata root may have anti-inflammatory effects (6; 11). The effects of suma with anti-inflammatory agents are not well understood.
- Antilipemic agentsAntilipemic agents: Based on secondary sources, suma root may contain up to 11% saponins, which may be responsible for its effects in lowering blood cholesterol, particularly by binding with bile acids and cholesterol. Theoretically, concurrent use of suma and antilipemic agents may cause added cholesterol-lowering effects.
- Antineoplastic agentsAntineoplastic agents: Based on in vitro and animal study, suma may have various anticancer activities, such as cytotoxic effects (1), reduction of angiogenesis (10), inhibition of tumor growth (6), reduction in neoplastic lesions (2), and inhibition of spontaneous leukemia (3). The effects of suma with antineoplastic agents are not well understood.
- Hormonal agentsHormonal agents: Based on animal study, suma may exert anabolic-like effects due to the presence of beta-ecdysterone, two types of phytosteroids (beta-sitosterol and stimasterol), and other compounds; in mice, treatment with Pfaffia paniculata was shown to increase plasma estradiol-17beta, progesterone, and testosterone levels (4). The effects of suma with hormonal agents are not well understood.
In modern Brazilian herbal medicine practices, suma root is employed as a cellular oxygenator and taken to stimulate appetite and circulation, increase estrogen production, balance blood sugar levels, enhance the immune system, strengthen the muscular system, and enhance memory.
In North American herbal medicine, suma root is used as an adaptogenic and regenerative tonic regulating many systems of the body; as an immunostimulant; to treat exhaustion and chronic fatigue, impotence, arthritis, anemia, diabetes, cancer, tumors, mononucleosis, high blood pressure, PMS, menopause, and hormonal disorders, and many types of stress. In herbal medicine in Ecuador today, suma is considered a tonic and „normalizer“ for the cardiovascular system, the central nervous system, the reproductive system, and the digestive system; it is used to treat hormonal disorders, sexual dysfunction and sterility, arteriosclerosis, diabetes, circulatory and digestive disorders, rheumatism, and bronchitis. Thomas Bartram, in his book Encyclopedia of Herbal Medicine, reports that suma is used in Europe to restore nerve and glandular functions, to balance the endocrine system, to strengthen the immune system, for infertility, menopausal, and menstrual symptoms, to minimize the side effects of birth control medications, for high cholesterol, to neutralize toxins, and as a general restorative tonic after illness.
Die 5-Elementeanalyse bildet die Energiedynamik von Suma wie folgt ab:
|Blau bedeutet :||TCM-Quellen|
|Schwarz bedeutet :||Studien|
|Rot bedeutet:||Studien Hauptwirkung|
Zum Verständnis der Abkürzungen des Schaubildes siehe
Struktur – und Wandlungsmodell der chinesischen Medizin