//
du liest...
Ernährung, Natto

Natto – Bacillus subtilis/Sojabohnen

Dosis:  50- 300g/Tag. ( 2000 – 12000 FU)

Inhalt

1.         Metabolisches Syndrom  
2.         Thrombosen
3.         Vitamin K-Mangel
4.         Osteoporose
5.         Leaky gut Syndrom
6.         Durchblutungsstörungen periphere
7.         Krebs
8.         KHK
9.         Alzheimer  
10.      Antiaging
11.       Allgemeine Gesundheit  
12.       Falten
13.       Haarausfall
14.       Dupuytren/Peyronie
15.       Abwehrschwäche
16.       Bakterielle Infekte  
17.        Influenza
18.       Colitis
19.       Rückenschmerzen
20.       Testosteronmangel
21.       Depressionen
22.       Wundheilung
23.       Ekzem
24.       Alkoholvergiftung/Kater  

 

  1. Metabolisches Syndrom

Effect of soy on metabolic syndrome and cardiovascular risk factors: a randomized controlled trial.

Soy nutritional intervention resulted in a reduction in the number of MetS features in 13/26 subjects. Moreover, in the soy group we observed a significant improvement of median percentage changes for body weight (-1.5 %) and BMI (-1.5 %), as well as for atherogenic lipid markers, namely TC (-4.85 %), LDL-C (-5.25 %), non-HDL-C (-7.14 %) and apoB (-14.8 %). Since the majority of the studied variables were strongly correlated, three factors were identified which explained the majority (52 %) of the total variance in the whole data set. Among them, factor 1, which loaded lipid and adipose variables, explained the 22 % of total variance, showing a statistically significant difference between treatment arms (p = 0.002).

1.1.    Adipositas

Protective and curative effects of Bacillus subtilis SPB1 biosurfactant on high-fat-high-fructose diet induced hyperlipidemia, hypertriglyceridemia and deterioration of liver function in rats.

Whereas, the administration of Bacillus subtilis SPB1 biosurfactant to HFFD improved the body weight gain and serum lipids profile and reverted back near normal the activities of lipase and liver toxicity indicators. In addition, notable protective and curative effects were reported in liver tissues. Overall, these results suggest that the lipopeptides biosynthesized by Bacillus subtilis SPB1 achieved an anti-obesity effect through the inhibition of lipid digestive and liver dysfunction enzymes.

1-Deoxynojirimycin isolated from a Bacillus subtilis stimulates adiponectin and GLUT4 expressions in 3T3-L1 adipocytes.

Our findings indicate that DNJ may greatly facilitate glucose uptake into adipose tissues by increasing the action of adiponectin via its up-regulated expression as well as its receptor genes.

1.2.    Hypercholesterinämie

Effects of Bacillus subtilis var. natto and Saccharomyces cerevisiae fermented liquid feed on growth performance, relative organ weight, intestinal microflora, and organ antioxidant status in Landes geese

In conclusion, the results indicated that feeding geese with BAC and SAC mix FLF can improve growth and feed intake, modulate the intestine ecology, and decrease the blood cholesterol concentrations; it also can improve the antioxidative status of organs and breast muscle.

       – Inhibitory effect of natto, a kind of fermented soybeans, on LDL oxidation in vitro

The increase of conjugated dienes in LDL oxidized by copper and an azo pigment was depressed by the addition of LMWVS and SWE. These results demonstrate that natto fractions have inhibitory effects on LDL oxidation as a result of their radical scavenging activity.

–  Bacillus SubtilisFermented Red Bean (Red Bean Natto) Reduces Hyperlipidemia Levels in Hamsters Fed an Atherogenic Diet

The oral administration of Bacillus subtilis‐fermented red bean natto extract (RBNE), a popular Asian dessert, effectively moderated the metabolism of lipids and positively affected the blood and liver profiles of hamsters fed with a high‐cholesterol and high‐fat diet. Importantly, RBNE significantly suppressed the increase in visceral fat mass.

Effect of black soybean natto extract (Glycine soja) on reproduction system of hypercholesterolemia male mice

Black soybean natto extract influenced on reproduction system of male hypercholesterolemic mice by increasing the testosterone level and increasing the density and motility of sperm.

Black soybean natto extract is promising as hypercholesterolemic therapy for treating the male reproduction system.

1.3.    Hypertonie

Inhibition of angiotensin I converting enzyme by subtilisin NAT (nattokinase) in natto, a Japanese traditional fermented food

Inhibition of ACE by subtilisin and its degradation peptides such as LY and FY may participate in the suppression of blood pressure by ingestion of natto.

Antihypertensive Effects of Natto, a Traditional Japanese Fermented Food, in Spontaneously Hypertensive Rats

The administration of the inhibitor, even at the lowest dose, resulted in a significant decrease in blood pressure 4 h after administration. Thus, the ACE inhibitor from natto appears to moderately reduce blood pressure relative to increases in dosage.

Relationship between Natto-added Feed and Blood Pressure of SHR

Fermented Soy Product Intake Is Inversely Associated with the Development of High Blood Pressure: The Japan Public Health Center-Based Prospective Study.

The intake of fermented soy products, but not total or nonfermented soy products, was inversely associated with developing high BP in men and women with normal BP.

Effect of γ-aminobutyric acid and nattokinase-enriched fermented beans on the blood pressure of spontaneously hypertensive and normotensive Wistar–Kyoto rats

The greatest antihypertensive effect was observed when the pharmacological treatment was administered. The effect of the daily intake of fermented beans containing GABA and nattokinase may be helpful in controlling blood pressure levels in hypertensive model animals. The fermentation of beans with B. subtilis B060 may therefore constitute a successful strategy for producing a functional food with antihypertensive activity.

Antihypertensive Effects of Continuous Oral Administration of Nattokinase and Its Fragments in Spontaneously Hypertensive Rats

These results suggest that nattokinase and its fragments are different from each other in the mechanism to reduce hypertension. Nattokinase, retained its protease activity after absorbance across the intestines, may decrease blood pressure through cleavage of fibrinogen in plasma. The fragments, which absorbed as nattokinase-degradation products, prevents the elevation of plasma angiotensin II level to suppress hypertension.

1.4.    Diabetes

Effect of Intake of Natto and Soybeans on Postprandial Blood Glucose Levels in Healthy Adults

After both the soybean and natto meals, the blood glucose level at 60 minutes after intake was significantly lower than after the control meal. However, only the natto meal, and not the soybean meal, significantly suppressed the rise in blood glucose level at 60 minutes compared to the control meal. Furthermore, the area under the glucose curve from 0 to 120 min after the natto meal was significantly smaller than for the control meal.These results suggest that natto is useful for the control of postprandial blood glucose level.

Consumption of soy foods and isoflavones and risk of type 2 diabetes: a pooled analysis of three US cohorts.

Intake of isoflavones was associated with a modestly lower T2D risk in US men and women who typically consumed low-to-moderate amounts of soy foods. These findings warrant replications in other populations with similar soy intake levels.

 

  1. Thrombosen 

      –  Effects of Bacillus subtilis var. natto products on symptoms caused by blood flow disturbance in female patients with lifestyle diseases.The significant improvement in the symptoms secondary to blood flow disturbance was caused by the improvement in blood flow by NKCP(®).  –  Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjectsAfter 2 months of administration, fibrinogen, factor VII, and factor VIII decreased 9%, 14%, and 17%, respectively, for the Healthy Group; 7%, 13%, and 19%, respectively, for the Cardiovascular Group; and 10%, 7%, and 19%, respectively, for the Dialysis Group, whereas blood lipids were unaffected by nattokinase. No significant changes of uric acid or notable adverse events were observed in any of the subjects. In summary, this study showed that oral administration of nattokinase could be considered as a CVD nutraceutical by decreasing plasma levels of fibrinogen, factor VII, and factor VIII.

     – Anticoagulant and fibrinolytic effects of functional food materials produced by Bacillus subtilis natto

Although both NSK-SDR and NKCPR reduced fibrin monomer levels in human blood, the anticoagulant effect of NKCPR was over 100-fold higher than that of NSK-SDR. Dietary supplements with anticoagulant and fibrinolytic effects might play an important role in preventing thrombotic diseases.

–  Thrombolytic effects in vivo of nattokinase in a carrageenan-induced rat model of thrombosis

Both the histological and physiological evidence from this study indicate that nattokinase exerts thrombolytic effects in vivo

–  Fibrinolytic and anti-thrombotic effect of NKCP, the protein layer from Bacillus subtilis (natto)

These results suggest that the oral administration of NKCP can be expected to have a fibrinolytic effect and cause positive changes in local blood flow.

 

3.         Vitamin K-Mangel

Effect of biofilm formation by Bacillus subtilis natto on menaquinone-7 biosynthesis

Bacillus subtilis natto is the key microorganism for the industrial production of menaquinone-7.

Accumulation of Vitamin K (Menaquinone-7) in Plasma after Ingestion of Natto and Natto Bacilli (B. subtilis natto)

This means that the natto bacilli influences vitamin K production in the digestive system. In both cases, there was no difference observed in the blood coagulation or fibrinolytic systems tested by TEG pattern and PT, APTT.

 

4.         Osteoporose

Prolonged Intake of Fermented Soybean Diets with Supplementation of Isoflavone and Saponin Prevents Bone Loss in Ovariectomized Rats

This study demonstrates that the intake of natto diets supplemented with nijiru containing isoflavone and saponin has a preventive effect on OVX-induced bone loss, suggesting that it may have a role in the prevention of osteoporosis.

Promotion of Bone Formation by Fermented Soybean (Natto) Intake in Premenopausal Women

In premenopausal women who had to keep the stiffness index as high as possible before menopause, Natto intake may have contributed to the promotion of bone formation.

Intake of fermented soybeans, natto, is associated with reduced bone loss in postmenopausal women: Japanese Population-Based Osteoporosis (JPOS) Study.

Natto intake may help prevent postmenopausal bone loss through the effects of menaquinone 7 or bioavailable isoflavones, which are more abundant in natto than in other soybean products.

 

5.         Leaky Gut Syndrom

Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers.

The key findings of the present study is that oral spore-based probiotic supplementation reduced symptoms indicative of „leaky gut syndrome“.

 

  1. Durchblutungsstörungen periphere

Effects of Bacillus subtilis var. natto products on symptoms caused by blood flow disturbance in female patients with lifestyle diseases

Fermented soya extract with subtilisin NAT (nattokinase) as the main component was used as an active placebo. A 4-week course of NKCP® significantly decreased the visual analog scale (VAS) score for shoulder stiffness from 42.3 to 32.4 (P=0.009), the VAS score for low back pain from 25.5 to 18.8 (P=0.02), and the VAS score for coldness of the extremities from 33.1 to 25.7 (P=0.002).

 

  1. Krebs 

A Contact Antitumor Activity of Bacillus natto on Solid Type Ehrlich Carcinoma Cells

Antitumor Activity of Bacillus natto. VI. Analysis of Cytolytic Activity on Ehrlich Ascites Carcinoma Cells in the Culture Medium of Bacillus natto KMD 1126

As a result of the analysis of the cytolytic activity, surfactin (I), protease (II), and an acidic substance (III) were separated from the culture filtrate. I, II, and III had no cytolytic activity but a mixture of I, II, and III showed a cytolytic activity, same as that of the culture filtrate.

Cytotoxicity and Apoptosis-Inducing Effect of Soybean Broth Cultured with Microorganisms Used in the Production of Fermented Soybean Foods on Human Monoblastic Leukemia U937 Cells

Thus, SB was conferred cytotoxicity upon culturing with the microorganisms used in this study; in particular, SB cultured with A. sojae induced apoptosis in U937 cells.

Studies on the Anticancer Mechanisms of the Natto Extract

As a result, all cancer cells perished the next day. On the other hand, if only a protein related extract from boiled beans and fermented soybean bacterium was added, there were no changes in cell growth. We purified and investigated amino acid sequence of anti-cancer peptide from Natto using Butyl Sepharose column chromatography of 5-kDa peptide. The peptide appeared to be a new antibacterial peptide.

Soy consumption reduces the risk of non-small-cell lung cancers with epidermal growth factor receptor mutations among Japanese

Soybean products demonstrated a protective association with EGFR mutated, but not EGFR wild-type NSCLCs, with multivariate-adjusted odds ratios and 95% confidence intervals for the 2nd and 3rd tertile of soybean product consumption of 0.79 (0.50–1.27) and 0.56 (0.34–0.93) relative to those in the lowest tertile (trend P = 0.023). In conclusion, soy consumption may exert a protective association against the development of NSCLCs with EGFR mutations, providing possible insights into mechanisms of their genesis.

Soy Consumption and the Risk of Prostate Cancer: An Updated Systematic Review and Meta-Analysis.

Combined, this evidence from observational studies shows a statistically significant association between soy consumption and decreased PCa risk. Further studies are required to support soy consumption as a prophylactic dietary approach to reduce PCa carcinogenesis.

Dietary isoflavone intake and all-cause mortality in breast cancer survivors: The Breast Cancer Family Registry.

In this large, ethnically diverse cohort of women with breast cancer living in North America, a higher dietary intake of isoflavone was associated with reduced all-cause mortality. Cancer 2017;123:2070-2079. © 2017 American Cancer Society.

Soy Intake Is Associated With Lower Endometrial Cancer Risk: A Systematic Review and Meta-Analysis of Observational Studies.

Dietary soy intake was inversely associated with endometrial cancer risk with an overall RE of 0.81 (95% CI: 0.72, 0.91). In subgroup analyses, a statistically significant protective effect of soy intake was found for unfermented soy food (RE: 0.81, 95% CI: 0.67, 0.97), postmenopausal women (RE: 0.76, 95% CI: 0.61, 0.95), and Asian (RE: 0.79, 95% CI: 0.66, 0.95) and non-Asian population (RE: 0.83, 95% CI: 0.71, 0.96). Current evidence indicates that soy food intake is associated with lower endometrial cancer risk.

Effect of Black Soybean Extract on the Suppression of the Proliferation of Human AGS Gastric Cancer Cells via the Induction of Apoptosis

The results of the present study indicated that black soybean extract could be used as an apoptosis inducer in AGS cells and a natural chemopreventive agent in the treatment of human gastric cancer

Induction of apoptosis in human leukemia K562 cells by cyclic lipopeptide from Bacillus subtilis natto T-2

The results of fluorescent staining indicated that CLP brought about apoptosis in K562 cells. Flow cytometric analysis also demonstrated that CLP caused dose-dependent apoptosis of K562 cells through cell arrest at G1 phase. Western blotting revealed that CLP-induced apoptosis in K562 cells was associated with caspase-3 and poly(ADP-ribose)polymerase (PARP) protein. It is estimated that CLP inhibited proliferation in K562 cells by inducing apoptosis.

 

  1. KHK

     

    –  Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjectsAfter 2 months of administration, fibrinogen, factor VII, and factor VIII decreased 9%, 14%, and 17%, respectively, for the Healthy Group; 7%, 13%, and 19%, respectively, for the Cardiovascular Group; and 10%, 7%, and 19%, respectively, for the Dialysis Group, whereas blood lipids were unaffected by nattokinase. No significant changes of uric acid or notable adverse events were observed in any of the subjects. In summary, this study showed that oral administration of nattokinase could be considered as a CVD nutraceutical by decreasing plasma levels of fibrinogen, factor VII, and factor VIII.

Dietary soy and natto intake and cardiovascular disease mortality in Japanese adults: the Takayama study.

The highest quartile of natto intake compared with the lowest intake was significantly associated with a decreased risk of mortality from total CVD after control for covariates: the HR was 0.75 (95% CI: 0.64, 0.88, P-trend = 0.0004).

Dietary flavonoid intake and cardiovascular risk: a population-based cohort study.

Flavonoid intake was inversely associated with CV risk, CV non-fatal events and all-cause mortality in a cohort with a low consumption of soy, tea and cocoa, which are typically viewed as the foods responsible for flavonoid-related benefits.

Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease

Studies also indicate that NK can ameliorate other diseases such as hypertension [4], stroke [17], Alzheimer’s disease [18], and atherosclerosis [19]. The potential of using NK to decrease atherothrombotic risk and slow the progression of atherosclerosis as well as cognitive decline is currently being assessed in a Phase II clinical trial (ClinicalTrials.gov Identifier: NCT02080520, 28 May 2015).

 

  1. Alzheimer

     

    Amyloid-degrading ability of nattokinase from Bacillus subtilis nattoIn this study, we explored the amyloid-degrading ability of nattokinase, a fibrinolytic subtilisin-like serine protease, and determined the optimal conditions for amyloid hydrolysis. This ability is shared by proteinase K and subtilisin Carlsberg, but not by trypsin or plasmin.

Neuroprotective effects of fermented soybean products (Cheonggukjang) manufactured by mixed culture of Bacillus subtilis MC31 and Lactobacillus sakei 383 on trimethyltin-induced cognitive defects mice.

These results demonstrate that CGK fermented by mixed culture of B. subtilis and L. sakei could exert a wide range of beneficial activities for neurodegenerative diseases, including Alzheimer, Parkinson, and Huntington disease.

An improved Bacillus subtilis cell factory for producing scyllo-inositol, a promising therapeutic agent for Alzheimer’s disease.

The B. subtilis cell factory was improved to yield an SI production rate of 10 g/L/48 h at least. The improved conversion was achieved only in the presence of enriched nutrition in the form of 2% (w/v) Bacto soytone in the medium, which may be due to the increasing demand for regeneration of cofactors.

Attenuation of neurobehavioral and neurochemical abnormalities in animal model of cognitive deficits of Alzheimer’s disease by fermented soybean nanonutraceutical.

These findings clearly indicated that NN reversed colchicine-induced behavioral and neurochemical alterations through potent antioxidant activity and could possibly impart beneficial effects in cognitive defects associated with Alzheimer’s disease.

Surfactin exhibits neuroprotective effects by inhibiting amyloid β-mediated microglial activation.

These results suggest that surfactin impairs the Aβ-induced inflammatory response of microglial cells and confers protection against indirect neurotoxicity to hippocampal cells. Our findings indicate that surfactin may have therapeutic potential for ameliorating Alzheimer’s disease as well as other neurodegenerative disorders which involve neuroinflammation.

 

  1. Antiaging

–  Dietary and microbiome factors determine longevity in Caenorhabditis elegans

Feeding the gram positive B. subtilis to C. elegans instead of the gram negative standard laboratory diet E. coli considerably increases worm longevity [14,17,19,21]. To understand the nature of this life span increase we first examined whether it is B. subtilis strain-specific. We fed worms three different WT strains of B. subtilis (PY79, 3610, and 168) and compared their longevity to worms fed the standard E. coli OP50. Worms fed any of the B. subtilis strains lived longer (43%-58%) than E. coli fed worms (Figure ​(Figure1A),1A), thus feeding B. subtilis to worms extends their life span independently of the B. subtilis strain used.

Natto (fermented soybean) extract extends the adult lifespan of Caenorhabditis elegans.

The water extract significantly prolonged the adult lifespan of the wild-type worms and rendered them resistant to oxidative and thermal stress. In addition, treatment with natto extract significantly delayed the accumulation of lipofuscin, a characteristic of aging cells. Our findings suggest that components of natto have a beneficial anti-aging effect in vivo.

Microbial flora, probiotics, Bacillus subtilis and the search for a long and healthy human longevity

We found that biofilm-proficient B. subtilis colonized the C. elegans gut and extended the worm lifespan significantly longer than did biofilm-deficient isogenic strains. In addition to biofilm proficiency, the quorum-sensing pentapeptide CSF and nitric oxide (NO) represent the entire B. subtilis repertoire responsible for the extended longevity of C. elegans. B. subtilis grown under biofilm-supporting conditions synthesized higher levels of NO and CSF than under planktonic growth conditions, emphasizing the key role of the biofilm in slowing host aging. Significantly, the prolongevity effect of B. subtilis was primarily due to a downregulation of the insulin-like signaling system that precisely is a key partaker in the healthy longevity of human centenarians. These findings open the possibility to test if the regular consumption of B. subtilis incorporated in foods and beverages could significantly extend human life expectancy and contribute to stop the development of age-related diseases

 

  1. Allgemeine Gesundheit

     

    Supplemental effects of probiotic Bacillus subtilis fmbJ on growth performance, antioxidant capacity, and meat quality of broiler chickens.In the study, dietary supplementation with BS fmbJ significantly improved (P < 0.05) the average daily gain (ADG), average daily feed intake (ADFI), and feed conversion ratio (FCR) of broilers from 21 to 42 d and 1 to 42 d. At 42 d, the final body weight was increased (P < 0.05) in BS-2 group compared with that in CON. Dietary BS fmbJ significantly increased (P < 0.05) serum IgA and IgG concentrations of broilers after 42 days raising. The glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) activity of serum and liver were increased (P < 0.05), and methane dicarboxylic aldehyde (MDA) contents in serum and liver were decreased (P < 0.05) by BS fmbJ added into the broiler diets.

 

  1. Falten

       –  Stimulating effects of Bacillus subtilis natto-fermented Radix astragali on hyaluronic acid production in human skin cells.

It appeared that isoflavonoid aglyhttps://www.ncbi.nlm.nih.gov/pubmed/19619633cones or other metabolites, converted from their primary isoflavones during fermentation, might be responsible for the skincare functions found in this study. This study demonstrated the low toxicity and the stimulating effects of HQB on HA synthesis, and suggests that HQB may play a promising role in anti-aging cosmetic applications.

 

  1. Haarausfall– In vivo hair growth promotion effects of ultra-high molecular weight poly-γ-glutamic acid from Bacillus subtilis (Chungkookjang).The number of hair follicles on the relative area of shaved skin in the UHMW γ-PGA-treated group was higher than that observed on the shaved skin in the control group. These results indicate that UHMW γ-PGA can promote hair growth by effectively inducing the anagen phase in telogenic C57BL/6 mice.
  2. Dupuytren/PeyronieAmyloid-degrading ability of nattokinase from Bacillus subtilis nattoIn this study, we explored the amyloid-degrading ability of nattokinase, a fibrinolytic subtilisin-like serine protease, and determined the optimal conditions for amyloid hydrolysis. This ability is shared by proteinase K and subtilisin Carlsberg, but not by trypsin or plasmin.

 

  1. AbwehrschwächeProbiotic strain Bacillus subtilis CU1 stimulates immune system of elderly during common infectious disease period: a randomized, double-blind placebo-controlled studyTaken together, our study provides evidence that B. subtilis CU1 supplementation during the winter period may be a safe effective way to stimulate immune responses in elderly subjects.- Immunomodulatory effects of Bacillus subtilis (natto) B4 spores on murine macrophagesThese results demonstrate that B. subtilis (natto) B4 spores are harmless to murine macrophages and can stimulate their activation through up-regulation of ACP and LDH activities and enhance their immune function by increasing iNOS activity and stimulating NO and cytokine production. The above findings suggest that B. subtilis (natto) B4 spores have immunomodulatory effects on macrophages.

Bacillus subtilis Improves Immunity and Disease Resistance in Rabbits

In conclusion, dietary supplementation with B. subtilis for rabbits could improve growth performance, intestinal homeostasis, and immune organ index and enhance innate immune response as well as disease resistance. These findings showed that the induction of β-defensin by B. subtilis might be an interesting new therapeutic strategy to strengthen innate defense mechanisms.

 

  1. Bakterielle Infekte –  Bacillus subtilis from soybean food shows antimicrobial activity for multidrug-resistant Acinetobacter baumannii by affecting AdeS geneThe isolated strain belongs to Bacillus subtilis according to 16S RNA analysis. Furthermore, E. coli showed multidrug resistance when it was transformed withAdeS gene from A. baumannii while the resistant bacteria could be inhibited completely by isolated Bacillus subtilis. Thus, probiotics from soybean food provides potential antibiotics for multidrug-resistant pathogenic bacteria.

 

  1. Influenza

Anti-influenza Activity of a Bacillus subtilis Probiotic Strain.

The protective effect of P18 in mice was comparable to that of oseltamivir phosphate (Tamiflu). Further study will assess the potential of peptide P18 as an antiviral compound and as a promising candidate for the development of new antiviral vaccines.

 

  1. Colitis

Effects of Bacillus subtilis on Epithelial Tight Junctions of Mice with Inflammatory Bowel Disease

  1. subtilis intake upregulated expression of TJ proteins (claudin-1, occludin, JAM-A, and ZO-1), for improved barrier function, and downregulated cytokine expression (IL-6, IL-17, IL-23, and TNF-α) to reduce intestinal epithelial damage.

 

  1. Rückenschmerzen

Effects of Bacillus subtilis var. natto products on symptoms caused by blood flow disturbance in female patients with lifestyle diseases.

The significant improvement in the symptoms secondary to blood flow disturbance was caused by the improvement in blood flow by NKCP(®).

Effects of products containing Bacillus subtilis var. natto on healthy subjects with neck and shoulder stiffness, a double-blind, placebo-controlled, randomized crossover study

Headache score significantly improved in the NKCP® group compared to the placebo group. Moreover, NKCP® significantly improved the score of visual analogue scale for neck and shoulder stiffness and pain, reduced muscle stiffness of the neck, and increased the skin surface temperature of neck and shoulders, compared to before ingestion. No adverse effects were observed during this study.These results suggest that NKCP® may alleviate headaches and chronic neck and shoulder stiffness and pain.

 

  1. Depressionen

Soybeans or Soybean Products Consumption and Depressive Symptoms in Older Residents in Rural Northeast China: A Cross-Sectional Study.

Women had significantly higher prevalence of depressive symptoms than men in rural China. Individuals who rarely consume soybeans or soybean products are more likely to suffer depressive symptoms. Rural elderly residents should be cautiously screened to prevent or treat depression.

 

  1. Testosteronmangel

Effect of black soybean natto extract (Glycine soja) on reproduction system of hypercholesterolemia male mice

Black soybean natto extract influenced on reproduction system of male hypercholesterolemic mice by increasing the testosterone level and increasing the density and motility of sperm. Black soybean natto extract is promising as hypercholesterolemic therapy for treating the male reproduction system.

 

  1. Wundheilung

Nattokinase Crude Extract Enhances Cutaneous Wound Healing

NCE demonstrated the ability to promote wound healing in mouse skin-resection injuries. Relative to the other ingredients in the cultured supernatant, NCE has a more pronounced effect on epidermal regeneration and angiogenesis. The expression levels of Oct-4 and Nanog in the skin tissue of the NCE-treated group were significantly higher. This study reveals a new role for NK in cutaneous wound healing and demonstrates that NCE extends the application of NK.

 

  1. Ekzem

Maternal Intake of Natto, a Japan’s Traditional Fermented Soybean Food, during Pregnancy and the Risk of Eczema in Japanese Babies

High frequency intake of natto during pregnancy possibly reduces the incidence of eczema in children at 6 months of age.

 

  1. Alkoholvergiftung/KaterEffect of Bacillus natto-fermented product (BIOZYME) on blood alcohol, aldehyde concentrations after whisky drinking in human volunteers, and acute toxicity of acetaldehyde in miceThe breath alcohol concentration in the administered group (0.18 +/- 0.11 mg/l) was found to be lowered about 44% than that of the control group (0.32 +/- 0.11 mg/l) (p < 0.0005, n = 21), at 1 hr after drinking whisky. In acute toxicity experiments of aldehyde in mice (12 mmol AcH/mg), BIOZYME showed the survival effect as with alpha-D-Ala (134% increase of the living, at 40 min after i.p. administration) (p < 0.005, n = 22). These findings reveal the Bacillus natto produced BIOZYME as a reasonable, safety and useful anti-hangover agent.

 

Epidemiologie

30% less risk of dying from a stroke if you eat lots of ‘natto’

Maternal intake of Natto, a Japan’s traditional fermented soybean food, during pregnancy and the risk of eczema in Japanese babies.

Wirkungen:

Produziert Poly-γ-Glutamic Acid.
Mit Scutellaria wird Produktion von baicalin and wogonoside angekurbelt: https://www.ncbi.nlm.nih.gov/pubmed/27141673

Mit coagulans kombinierbar, sogar besser zusammen
Erhöht Fleischqualität: https://www.ncbi.nlm.nih.gov/pubmed/26954164

main component is bacillopeptidase F, has antithrombotic, fibrinolytic, and blood pressure-lowering effects

other applications attributed to Nattokinase including treatment of hypertension, Alzheimer’s disease, and vitreoretinal disorders

used to increase weight gain of an animal, to increase feed utilization efficiency, to reduce morbidity, to increase disease resistance, to increase survival rates, to increase the immune response of the animal and to maintain healthy gut microflora

Vitamin K derivative is accumulated

proziert Rapamycin

So erzeugt der gentechnisch angestachelte Bacillus subtilis in großen Mengen Vitamin B2

Bacterial degradation of spermine and expression of spermidine/spermine acetyltransferase in Bacillus subtilis (natto) under liquid cultivation

One animal study conducted by researchers at Shizuoka Prefectural University and the food-processing company Fujicco Co., showed that the black soybean is more effective than the yellow soybean in preventing menopausal symptoms. The study found that menopausal rats, whose ovaries had been removed, showed a significantly higher decline in their blood-cholesterol level when given feed containing black soybeans, compared to those fed yellow soybeans. After four weeks, the blood cholesterol level of the black soybean group was up to 31 percent lower than a third group fed without soybeans, while the yellow soybean group was only a maximum of 16 percent lower

Natto and viscous vegetables in a Japanese style meal suppress postprandial glucose and insulin responses.

What Can Nattokinase Do for Me?

  1. Lower Blood Pressure

Nattokinase thins the blood and dissolves accumulated solids in it. Consequently blood pressure is lowered.

2. Reduce Pain

Because of its anti-inflammatory effects, nattokinase has been used to help with pain from arthritis, including that of rheumatoid arthritis. Women with painful periods, especially if the pain is caused by fibroids or endometriosis, may find that their pain is reduced with a nattokinase supplement.

3. Dissolve Clots

Because nattokinase is an enzyme, it can dissolve proteins like fibrin, which are a cause of clots and blockages in the blood in the first place.

4. Facilitate Brain Function

Because nattokinase thins and cleans up the blood the resulting improved circulation improves oxygenation to the brain. This can reduce brain fog and may lower the risk of Alzheimer’s disease.

5. Assist Vision

Nattokinase have been used to treat cataracts and eye floaters because of its ability to dissolve proteins and fibers that are the cause of these eye issues.

6. Increase Fertility

Fibroids and endometriosis are both chronic and painful conditions that can cause infertility.  Nattokinase can be used in these conditions to help dissolve the fibroids and endometriosis.

7. Improve Libido

Because nattokinase improves circulation as it thins bloods and breaks up congestion, it is helpful for low libido in men, especially when the low libido is caused by poor circulation.

8. Eliminate Migraines

Migraines can have many causes. For those whose migraines are caused by thick blood and poor circulation, regular use of nattokinase can solve the root cause of migraines.

9. Relieve Edema

A common theme edema is poor circulation. Because nattokinase improves circulation, a benefit of nattokinase is a reduction in edema. Clots in the legs (deep vein thrombosis) can also cause edema. Nattokinase addresses this cause of edema as well.

10. Heal Varicose Veins

The blood thinning and oxygenating properties of nattokinase make it an appropriate remedy for varicose veins. Hemorrhoid sufferers will be glad to know that nattokinse works for hemorrhoids as well since hemorrhoids are a type of varicose vein.

 

Contribution of a Fermentation Process using Bacillus subtilis (natto) to High Polyamine Contents of Natto, a Traditional Japanese Fermented Soy Food

The steaming process slightly decreased spermidine in soybeans, and the subsequent fermentation process resulted in 41.1% increase of spermidine and 19.4% reduction of spermine compared with those of steamed soybeans.

Effect of Bacillus subtilis natto on growth performance in Muscovy ducks

Weight gain, feed intake and feed conversion efficiency of Muscovy ducks were significantly improved by the dietary addition of Bacillus subtilis natto, and the results were more significant in 0.4% dietary Bacillus subtilis natto treatment group; Also, Bacillus subtilis natto reduced Escherichia coli and Salmonella colonies, and increased lactobacilli population in the ileum and the cecum. Biochemical parameters, including total protein, GOT (glutamic oxaloacetic transaminase), GPT (glutamic pyruvic transaminase), AKP (alkaline phosphatase), triiodothyronine (T3) and tetraiodothyronine (T4) contents (p<0.05) in the serum of Muscovy ducks were significantly improved (p<0.01), while urea nitrogen, glucose, triglyceride, total cholesterol concentrations decreased when Bacillus subtilis natto was added to the diets (p<0.05), and improved duodenum and immune functions.

The results of the present study indicate that diets with 0.4% Bacillus subtilis natto improved the growth performance of Muscovy ducks by increasing the absorption of protein, simulating hormone secretion, suppressing harmful microflora, and improving the duodenal structure and immune functions of Muscovy ducks. It is suggested that Bacillus subtilis natto is a potential candidate to be used use as a probiotic to improve the growth performance of Muscovy ducks.

 

Artikel

 

http://undergroundhealthreporter.com/natto-benefits-live-longer-like-japanese/

Recycling Metchnikoff: Probiotics, the Intestinal Microbiome and the Quest for Long Life

Dietary and microbiome factors determine longevity in Caenorhabditis elegans

Latest Research on Natto Revealed at Health Food Seminar in Tokyo

https://draxe.com/natto/

Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease

Studies also indicate that NK can ameliorate other diseases such as hypertension [4], stroke [17], Alzheimer’s disease [18], and atherosclerosis [19]. The potential of using NK to decrease atherothrombotic risk and slow the progression of atherosclerosis as well as cognitive decline is currently being assessed in a Phase II clinical trial (ClinicalTrials.gov Identifier: NCT02080520, 28 May 2015).

Bacillus subtilis natto fermentation to improve aglycone isoflavones content of black soybean varieties detam 2

After fermentation, both genistein and daidzein concentration increased up to 8 times as much as those in the raw soybean.

Stinky Soy Goo Could Fight Alzheimer’s

https://www.earthclinic.com/supplements/nattokinase.html

Natto Benefits Create Long Healthy Lives for the Japanese

 

Herstellung von Natto

Zutaten

–          Getrocknete Sojabohnen
–          Natto-Starter

Am besten sind getrocknete schwarze Sojabohnen. Diese gibt’s in japanischen Supermärkten, z.B. Hanaromarkt, Friedrich-Ebertstr. 20, Düsseldorf und kostet das kg 3,60 €. Man auch die normalen gelben Sojabohnen verwenden. Die Nattosporen (Natto-Starter) gibt’s hier: https://www.nattostarter.com/nattostarter.php

Zubereitung

  1. Bohnen im Schnellkochtopf weich kochen, Wasser abgießen und handwarm abkühlen lassen. Etwas Wasser dabei lassen, damit genug Feuchtigkeit da ist.
  2. In einer Schüssel die Bohnen mit Nattosporen bestreuen. Für 500g nimmt man einen viertel Teelöffel voll. Gut umrühren, damit die Sporen sich verteilen.
  3. Bohnen auf einem Backblech verteilen. Mit Klarsichtfolie überziehen, diese dann an einigen Stellen einstechen, damit etwas Luft zirkulieren kann.
  4. Die Bohnen auf dem Backblech bei 40 Grad ca. 24 Stunden brüten. Wenn der Backofen nicht auf 40 Grad einstellbar ist mit einem Kochthermometer die Einstellung justieren und überwachen

Nach dem Brutvorgang sieht man auf den Bohnen einen weißen, schleimigen Überzug, der  klebrige Fäden zieht bei ihrer Entnahme.

Die Bohnen kann man im Kühlschrank mehrere Tage aufbewahren und auch portioniert einfrieren.

TCM

 

Die 5-Elementeanalyse bildet die Energiedynamik von Natto/Bacillus subtilis wie folgt ab:

Schwarz :          Studien
Rot:                   Studien Hauptwirkung

Zum Verständnis der Abkürzungen des Schaubildes siehe

Struktur – und Wandlungsmodell der chinesischen Medizin

http://www.chinesischemedizin.com/CMS/index.php/struktur-und-wandlungsmodell.html

 

Advertisements

Diskussionen

Es gibt noch keine Kommentare.

Kommentar verfassen

Trage deine Daten unten ein oder klicke ein Icon um dich einzuloggen:

WordPress.com-Logo

Du kommentierst mit Deinem WordPress.com-Konto. Abmelden /  Ändern )

Google+ Foto

Du kommentierst mit Deinem Google+-Konto. Abmelden /  Ändern )

Twitter-Bild

Du kommentierst mit Deinem Twitter-Konto. Abmelden /  Ändern )

Facebook-Foto

Du kommentierst mit Deinem Facebook-Konto. Abmelden /  Ändern )

w

Verbinde mit %s

%d Bloggern gefällt das: