Anethum graveolens – Dill

Dosis:  2-5g/Tag

Inhalt

1. Herzhypertrophie
2. Hauterschlaffung
3. Refluxösophagitis
4. Progesteronmangel/Verhütung
5. Diabetes
6. Hypercholesterinämie
7. Dysmenorrhoe
8. Altersflecke
9. Gedächtnisschwäche


1. Herzhypertrophie

Dill Extract Induces Elastic Fiber Neosynthesis and Functional Improvement in the Ascending Aorta of Aged Mice with Reversal of Age-Dependent Cardiac Hypertrophy and Involvement of Lysyl Oxidase-Like-1

DE treatment, especially at 10%, of aged mice protected pre-existing elastic lamellae, reactivated tropoelastin and LOXL-1 expressions, induced elastic fiber neo-synthesis, and decreased the stiffness of the aging aortic wall, probably explaining the reversal of the age-related cardiac hypertrophy also observed following the treatment. DE could thus be considered as an anti-aging product for the cardiovascular system.



2. Hauterschlaffung

A blackberry-dill extract combination synergistically increases skin elasticity

The blackberry extract induced elastin gene expression, elastin promoter activity and inhibited elastic fibre degradation by matrix metalloproteinases (MMPs) 9 and 12. The dill extract induced elastin, collagen and LOXL1 gene expression, resulting in enhanced fibre cross-linking in human skin explants. Clinically, the blackberry and dill combination treatment displayed synergistic pro-elasticity activity as compared to each ingredient alone and placebo. Taken together, these results demonstrated the two multimodal plant-based extracts complemented each other in terms of bioactivity and resulted in a synergistic elastogenesis induction.

LOXL as a target to increase the elastin content in adult skin: a dill extract induces the LOXL gene expression

One extract, obtained from dill (LYS’LASTINE V, Engelhard, Lyon, France), stimulates the LOXL gene expression in dermal equivalents (+64% increase in the LOXL mRNA level when compared with control). At the same time, the elastin detection is increased in dermal equivalents and under the dermal–epidermal junction of skin equivalents, without increase of the elastin mRNA. In conclusion, LOXL can be considered as a new target to reinduce elastogenesis. Its stimulation by a dill extract is correlated with increased elastin detection, suggesting an increase in elastogenesis efficiency.

Evaluation of the efficacy of a dill extract in vitro and in vivo

Using the bio-tribometer, we first showed that the lateral elasticity of dermis equivalents (DEs) treated with the dill extract at 1% was significantly increased by +29% (P < 0.01) when compared to untreated DEs. In vivo, skin firmness and elastic recovery measured using cutometry methods were also significantly improved compared to placebo in volunteers treated for 56 days with a formula containing 1% of dill extract. Moreover, the clinical evaluation evidenced significant improvements in ’skin elasticity‘ compared to placebo. A majority of subjects treated with the dill extract also noted significant improvements in skin elasticity, firmness and slackness of the jaw line.

3. Refluxösophagitis

Anti-Inflammation and Protective Effects of Anethum graveolens L. (Dill Seeds) on Esophageal Mucosa Damages in Reflux Esophagitis-Induced Rats

AGS inhibited cellular inflammation including NO production and the expression of inflammatory proteins (iNOS and COX2 etc.), cytokines (IL-1β and TNF-α) and nuclear transfer factor related to NF-κB signaling caused by LPS stimulation in vitro. Furthermore, reflux esophagitis-induced rats were used to observe the anti-inflammatory effect of AGS. Tissue staining and inflammation-related protein expression of rats with acute reflux esophagitis indicated that AGS improved this inflammatory response, such as COX-2 and TNF-α in mucosa.



4. Progesteronmangel – Verhütung

Effects of Anethum graveolens L. (dill) on Oocyte and Fertility of Adult Female Rats

It is concluded that Anethum graveolens seed aqueous extract both in low dose and high dose increased estrous cycle duration and progesterone concentration and induced infertility without any significant adverse effects on oocytes’ developmental potential such as structural and chemical changes. Therefore, dill has the potential for study as the herbal extract with contraceptive property.

Anti-Fertility Effects of Different Fractions of Anethum Graveolens L. Extracts on Female Rats

Results showed that each fraction produced some changes such as hormonal level reduction (chloroform fraction), diestrus phase prolongation and infertility (water fraction), and increase in pregnancy duration (chloroform and ether fractions). We concluded that each fraction comprises only some of the mentioned components and therefore recommended the usage of crude extract, especially the aqueous one, in case infertility aims to be induced.



5. Diabetes

The effects of Anethum graveolens (dill) powder supplementation on clinical and metabolic status in patients with type 2 diabetes

The dill powder supplementation significantly decreased the mean serum levels of insulin, homeostatic model assessment of insulin resistance, low-density lipoprotein cholesterol, total cholesterol and malondialdehyde in the intervention group in comparison with the baseline measurements (P < 0.05). Furthermore, the mean serum levels of high-density lipoprotein and total antioxidant capacity were significantly increased in the intervention group in comparison with the baseline measurement (P < 0.05). Colonic motility disorder was the only gastrointestinal symptom whose frequency was significantly reduced by supplementation (P = 0.01). The mean changes in insulin, low-density lipoprotein cholesterol, total cholesterol and malondialdehyde were significantly lower in the intervention group than in the control group (P < 0.05). In addition, the mean changes in high-density lipoprotein were significantly higher in the intervention group than in the control group (P < 0.05).



6. Hypercholesterinämie

The effects of Anethum graveolens (dill) powder supplementation on clinical and metabolic status in patients with type 2 diabetes

The dill powder supplementation significantly decreased the mean serum levels of insulin, homeostatic model assessment of insulin resistance, low-density lipoprotein cholesterol, total cholesterol and malondialdehyde in the intervention group in comparison with the baseline measurements (P < 0.05). Furthermore, the mean serum levels of high-density lipoprotein and total antioxidant capacity were significantly increased in the intervention group in comparison with the baseline measurement (P < 0.05). Colonic motility disorder was the only gastrointestinal symptom whose frequency was significantly reduced by supplementation (P = 0.01). The mean changes in insulin, low-density lipoprotein cholesterol, total cholesterol and malondialdehyde were significantly lower in the intervention group than in the control group (P < 0.05). In addition, the mean changes in high-density lipoprotein were significantly higher in the intervention group than in the control group (P < 0.05).



7. Dysmenorrhoe

Effect of Dill (Anethum graveolens) on the severity of primary dysmenorrhea in compared with mefenamic acid: A randomized, double-blind trial

There were no significant differences between three groups for demographic or descriptive variables. Comprising the VAS showed that the participants of Dill and mefenamic acid groups had lower significant pain in the 1st and the 2nd months after treatment, whereas in the placebo group this was only significant in the 2nd month (P < 0.05). Dill was as effective as mefenamic acid in reducing the pain severity in primary dysmenorrhea. Further studies regarding side-effects of Dill and its interactivity are recommended.



8. Altersflecke

HPLC Analysis and Skin Whitening Effects of Umbelliprenin-containing Extracts of Anethum Graveolens, Pimpinella Anisum, and Ferulago Campestris

Our results demonstrate that the same potential of umbelliprenin can be ascribed also to umbelliprenin-enriched plant extracts which reinforces enforce the widespread use of phyto-preparations for cosmetic purposes (e.g., A. graveolens).



9. Gedächtnisschwäche

The effects of Anethum graveolens essence on scopolamine-induced memory impairment in mice

Although phytoesrogens are not steroids, the beneficial effect of dill on memory, at least in part, may have been achieved by estrogenic receptors present in the brain. Thus dill essence could be promising in improving memory and cognition, mainly in postmenopausal women.

Wirkung

According to Prior’s Popular Names of English Plants, the name dill is derived from the Old Norse word, dilla, meaning to lull. Dill had been used to lull babies to sleep and ease colic. An infusion of seeds was used for flatulence and colic. Dill seeds are sedative, so as a result, were used for insomnia and headaches. Other medicinal uses included to encourage milk production in nursing mothers, and to suppress appetites.
https://herbguild.eastkingdom.org/wp-content/uploads/2017/11/tisane-2002-12.pdf

The health advantages of dill seed include its ability to increasedigestive health, as well as providingrelief from insomnia, hiccups, diarrhea, dysentery, menstrual disorders, respiratory disorders, and cancer

This plant has several remedies effects such as anti-diabetic, muscle spasms remover, pain relievers, anti-inflammatory, anti-convulsive, analgesic, diuretic, strengthen of stomach, appetite enhancer, anti-insomnia, breast milk increase, sedative, antivomiting and blood lipid lowering. 

Artikel

Evaluation of the efficacy of a dill extract in vitro and in vivo

Compositions and methods for treatment of symptoms of aging

Chemistry and biological activities of Anethum graveolens L. (dill) essential oil: A review