Ligustri lucidi, Fr. – NU ZHEN ZI – Ligusterfrüchte

Dosis: 5-18 g/Tag

Inhalt

1. Osteoporose
2. Arthrose
3. Entzündungen
4. Schmerzen
5. Depressionen
6. Hepatitis C
7. Krebs
8. Fettleber
9. Diabetes
10. Darmdysbiose
11. Hyperpigmentation
12. Graue Haare



1.  Osteoporose

Fructus Ligustri Lucidi in Osteoporosis: A Review of its Pharmacology, Phytochemistry, Pharmacokinetics and Safety

FLL provides a new option for the prevention and treatment of osteoporosis, which attracts rising interests in identifying potential anti-osteoporotic compounds and fractions from this plant. Further scientific evidences are expected from well-designed clinical trials on its bone protective effects and safety.



2. Arthrose

Intra-Articular Injection of Fructus Ligustri Lucidi Extract Attenuates Pain Behavior and Cartilage Degeneration in Mono-Iodoacetate Induced Osteoarthritic Rats

In conclusion, our data demonstrated that FLL effectively ameliorated pain response and protected chondrocytes and ECM from degradation in OA rats. FLL exerted the effect by increasing the resistance of cartilage to MIA-induced damage and preventing chondrocytes from TNF-α induced hypertrophy.



3. Entzündungen

Analgesic and anti-inflammatory activities of aqueous extracts of fructus Ligustri lucidi

These results suggest that anti-inflammatory mechanisms of AFLL might be correlated to the decrease in the level of malondialdehyde (MDA), iNOS and COX-2 in the edema paw via increasing the activities of CAT, SOD and GPx in the liver. Overall, the results showed that AFLL could serve as a natural source of antioxidant, analgesic and anti-inflammation.

Anti-Neuroinflammatory Effects and Mechanism of Action of Fructus ligustri lucidi Extract in BV2 Microglia

Collectively, FLLE effectively inhibited inflammatory response by suppressing the MAPK and NF-κB signaling pathways and inducing HO-1 in LPS-stimulated BV2 microglial cells. Our findings provide a scientific basis for further study of FLL as a candidate for preventing or alleviating neuroinflammation.

4.  Schmerzen

Analgesic and anti-inflammatory activities of aqueous extracts of fructus Ligustri lucidi

These results suggest that anti-inflammatory mechanisms of AFLL might be correlated to the decrease in the level of malondialdehyde (MDA), iNOS and COX-2 in the edema paw via increasing the activities of CAT, SOD and GPx in the liver. Overall, the results showed that AFLL could serve as a natural source of antioxidant, analgesic and anti-inflammation.



5. Depressionen

Phenol glycosides extract of Fructus Ligustri Lucidi attenuated depressive-like behaviors by suppressing neuroinflammation in hypothalamus of mice

Overall, pre-treatment with PG extract ameliorated LPS-induced depressive-like behaviors by repressing neuroinflammation in mice hypothalamus which was attributed to its suppression on activation of microglia and production of inflammatory cytokines via acting on TLR4 pathway, CaSR and RAS cascade associated with improving vitamin D metabolism.



6. Hepatitis C

Oleanolic acid and ursolic acid: novel hepatitis C virus antivirals that inhibit NS5B activity

In this study, we found that the FLL aqueous extract strongly suppressed HCV replication. Further high-performance liquid chromatography (HPLC) analysis combined with inhibitory assays indicates that oleanolic acid and ursolic acid are two antiviral components within FLL aqueous extract that significantly suppressed the replication of HCV genotype 1b replicon and HCV genotype 2a JFH1 virus. Moreover, oleanolic acid and ursolic acid exhibited anti-HCV activity at least partly through suppressing HCV NS5B RdRp activity as noncompetitive inhibitors. Therefore, our results for the first time demonstrated that natural products oleanolic acid and ursolic acid could be used as potential HCV antivirals that can be applied to clinic trials either as monotherapy or in combination with other HCV antivirals.



7. Krebs

7.1. Gliom

Fructus ligustri lucidi extracts induce human glioma cell death through regulation of Akt/mTOR pathway In Vitro and reduce glioma tumor growth in U87MG xenograft mouse model

The FLL extracts caused a decrease in the expression of mammalian target of rapamycin (mTOR) and the FLL extract-induced cell death was increased by the mTOR inhibitor rapamycin. The FLL extracts decreased the expression of survivin. Oral administration of FLL extracts in subcutaneous U87MG xenograft models reduced the glioma tumor volume. These findings indicate that the FLL extracts resulted in glioma cell death through regulation of the Akt/mTOR/survivin pathway in vitro and inhibited glioma tumor growth in vivo. These data suggest that the FLL extracts may serve as a potential therapeutic agent for malignant human gliomas.

7.2. Magenkrebs

Aqueous extracts of Fructus Ligustri Lucide induce gastric carcinoma cell apoptosis and G2/M cycle arrest

These results confirmed that FLL could induce apoptosis in human gastric carcinoma, the underlying molecular mechanisms, at least partially, through activation p21/p53 and suppression CDC2/cdc25C signaling in vitro.



8. Fettleber

Preventive effect of total glycosides from Ligustri Lucidi Fructus against nonalcoholic fatty liver in mice

These results suggest that the total glycosides are effective in the treatment of NAFL of mice. Their mode of action is associated with inhibiting SREBP-1c, LXR-α and IL-6 mRNA, reducing lipid synthesis factor SREBP-1c and LXR-α protein and gene expression, suppressing inflammatory responses, then decreasing serum lipid and hepatic lipid.



9. Diabetes

Anti-diabetic activity of aqueous extract of Fructus Ligustri Lucidi in a rat model of type 2 diabetes

Following FLL extract treatment, diabetic rat BW increased, while FI and FBG levels decreased. FLL extract increased glucose tolerance and decreased insulin tolerance. Following treatment with 300 and 600 mg/kg FLL extract, MDA levels reached 13.5 ± 0.9 nmol/ml and 13.8 ± 1.1 nmol/ml, respectively. Compared to MDA levels of 19.5 ± 1.1 nmol/ml in diabetic control group, MDA levels was decreased by 30.8 % and 29.0 % after the treatment with 300 and 600 mg/kg FLL extract, respectively, indicating alleviated oxidative stress. The results show that aqueous FLL extract has the potential to alleviate T2D, resulting in reduced FI and FBG, and increased BW. The anti-diabetic activity of FLL extract on T2D may be relevant to reduced oxidative stress burden.



10. Darmdysbiose

Fructus Ligustri Lucidi preserves bone quality through the regulation of gut microbiota diversity, oxidative stress, TMAO and Sirt6 levels in aging mice

Next, we investigated the effect of FLL on Sirt6 expression in the femurs and tibias of aging mice using western blot and IHC. As shown in Figure 6A–6D, the expression levels of Sirt6 in distal femurs and femoral heads of the vehicle-treated aging group were ~41% and ~30%, respectively, lower than those of vehicle-treated normal controls (p < 0.05). Interestingly, administration of FLL to aging mice significantly increased Sirt6 expression levels by ~44% in the femurs in comparison with those of vehicle-treated aging controls (p < 0.05).



11. Hyperpigmentation

Identification of Sitogluside as a Potential Skin-Pigmentation-Reducing Agent through Network Pharmacology

We identified 148 potential active ingredients from 14 TCMs, and based on the average “degree” of the topological parameters, the top five TCMs (Fructus Ligustri Lucidi, Hedysarum multijugum Maxim., Ampelopsis japonica, Pseudobulbus Cremastrae Seu Pleiones, and Paeoniae Radix Alba) that were most likely to cause skin-whitening through anti-inflammatory processes were selected. Sitogluside, the most common ingredient in the top five TCMs, inhibits melanogenesis in human melanoma cells (MNT1) and murine melanoma cells (B16F0) and decreases skin pigmentation in zebrafish.



12. Graue Haare

Effects of Chinese Herbal Extracts on Tyrosinase Activity and Melanogenesis

We also investigated that Chinese herbal extracts (Fallopia multiflora, Ligustrum lucidum ait, Angelica sinensis, and other Chinese herbal) to show significant increased activity for mushroom tyrosinase and melanogenesis in mouse melanocytes. Therefore, Chinese herbal extracts can be a potential agent for hair blackening to be used in cosmetic products.

Wirkung

FLL has the pharmacological effects of antibacterial, anti-inflammatory, lowering blood pressure and blood lipid, protecting liver, anti-cancer, anti-aging, anti-fatigue and cardiotonic action

Glossy privet is used for promoting growth and darkening of hair, reducing facial dark spots, rapid heartbeat (palpitations), achy joints (rheumatism), swelling, tumors, dizziness (vertigo), common cold, congestion, constipation, deafness, fever, headache, liver disease (hepatitis), trouble sleeping (insomnia), chronic fatigue syndrome (CFS), promoting youthfulness, and extending lifespan. It is also used to induce sweating, as a tonic, for improving immune function, and for reducing the side effects of cancer treatment (chemotherapy). Glossy privet is also used for blurred vision, dizziness, ringing in the ears (tinnitus), and sore back and knees.

Artikel


The Advances in Research on the Pharmacological Effects of Fructus Ligustri Lucidi
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