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Chinesische Heilkräuter, Lithospermi, Rd.

Lithospermum rubrum – ZI CAO – Steinsame


Lithospermum rubrum – ZI CAO – Steinsame

Dosis:  10-50g/Tag

Dies kalte Mittel hilft bei hitzebedingtem Schleim in Form von Krebs, Arthrose und Übergewicht. Insbesondere löst es Schleim in Haut und Gelenken und hilft so bei Arthrosen und Zuständen wie Psoriasis, bei denen die natürliche Ausscheidung von Schadstoffen über die Haut gestört ist. In der Folge lagern sich diese Stoffe ein und werden vom Immunsystem angegriffen.

  1. Arthrose

Shikonin inhibits inflammatory responses in rabbit chondrocytes and shows chondroprotection in osteoarthritic rabbit knee.

In vivo, both the cartilage damage and the elevated expression of MMP-1, MMP-3 and MMP-13 and the decreased expression of TIMP-1 were ameliorated in shikonin intra-articular injection knees compared to vehicle knees. Our findings indicated that shikonin have anti-inflammatory and chondro-protective effects and may be a potential therapeutic agent for the treatment of OA.

  1. Adipositas

In conclusion, OVX induced fat accumulation in the viscera, liver, and skeletal muscles, mostly due to decreased energy expenditure. The increased fat accumulation exacerbated insulin resistance and impaired glucose and lipid metabolism. PMA+LES treatment in OVX rats normalized fat accumulation by decreasing food intake and increasing energy expenditure through potentiating hypothalamic insulin signaling and restoring normal glucose and lipid metabolism. Therefore, PMA+LES may be useful for alleviating metabolic dysregulation in post-menopausal women.  

These findings suggest that Lithospermum erythrorhizon prevents obesity by inhibiting adipogenesis through downregulation of genes involved in the adipogenesis pathway and may be a useful dietary supplement for the prevention of obesity.

  1.      Krebs

3.1.    Darmkrebs

Enhancement of cisplatin-induced colon cancer cells apoptosis by shikonin, a natural inducer of ROS in vitro and in vivo.

Our findings suggest that the strategy to apply shikonin as a synergistic agent to cisplatin could be a highly efficient way to achieve anticancer synergism by inducing intracellular oxidative stress. Shikonin may be a promising candidate as a chemosensitizer to cisplatin-based therapy for cancer treatments.

3.2.    Brustkrebs

RIP1K and RIP3K provoked by shikonin induce cell cycle arrest in the triple negative breast cancer cell line, MDA-MB-468: necroptosis as a desperate programmed suicide pathway.

The current findings have revealed that shikonin provoked mitochondrial ROS production in the triple negative breast cancer cell line, which works as a double-edged executioner’s ax in the execution of necroptosis or apoptosis. The main route of cell death induced by shikonin is RIP1K-RIP3K-mediated necroptosis, but in the presence of Nec-1, apoptosis has prevailed. The present results shed a new light on the possible treatment of drug-resistant triple negative breast cancer.

3.3.    Magenkrebs

Mechanisms of (2-methyl-n-butyl) shikonin induced apoptosis of gastric cancer SGC-7901 cells

It can be concluded that MBS could inhibit SGC-7901 cell proliferation and induce apoptosis. Mitochondrial apoptosis pathway, ERK1/2 signal pathway and JNK signal pathway might be involved in this process.

  1.        Hautalterung

Lithospermum erythrorhizon extract protects keratinocytes and fibroblasts against oxidative stress.

These results suggest that LE-derived extracts may protect oxidative-stress-induced skin aging by inhibiting degradation of skin collagen, and that this protection may derive at least in part from the antioxidant phenolics present in these extracts.

  1.       Endometriose

Shikonin reduces endometriosis by inhibiting RANTES secretion and mononuclear macrophage chemotaxis.

The results indicate that shikonin inhibits the development of endometriosis by various mechanisms, including the inhibition of RANTES expression and the reduction of mononuclear cell migration to lesions. Therefore, shikonin may be a novel, useful and safe agent for treating endometriosis

  1.       Psoriasis

Suppressive effect of β, β-dimethylacryloyl alkannin on activated dendritic cells in an imiquimod-induced psoriasis mouse model

Mice treated with alkannin at varying concentration showed obvious remission in psoriasis-like skin lesion compared to control group, with decreased PASI score, obviously reduced vertical thickness of epidermis. Besides, alkannin treatment decreased the expression of IL-23 in skin lesion.


  1.        Colitis

Beneficial effect of shikonin on experimental colitis induced by dextran sulfate sodium in BALB/c mice

This is the first report of shikonin’s ability to attenuate acute UC induced by DSS. Shikonin acts by blocking the activation of two major targets: NF-κB and STAT-3, and thus constitutes a promising potential therapeutic agent for the management of the inflammatory bowel disease.

  1.       Kontaktdermatitis

Effect of lithospermi radix on contact dermatitis induced by dinitrofluorobenzene in mice

Topical application of 10 mg/mL of LR effectively inhibited skin lesions induced by repeated paintings with DNFB. Topical application of LR also inhibited hyperplasia, edema, spongiosis and infiltrations of mononuclear cells. In addition, production levels of total immunoglobulin and IgG1 in serum were decreased by using LR in vivo.

  1.        Wundheilung

Water extract of gromwell (Lithospermum erythrorhizon) enhances migration of human keratinocytes and dermal fibroblasts with increased lipid synthesis in an in vitro wound scratch model

Low-dose WG (1 μg/ml) enhances the migration of both CHK and fibroblasts with increased lipid synthesis in an in vitro wound scratch model.


Shikonin Promotes Skin Cell Proliferation and Inhibits Nuclear Factor-κB Translocation via Proteasome Inhibition In Vitro.



Die 5-Elementeanalyse bildet die Energiedynamik von Lithospermum wie folgt ab:


Blau bedeutet :  TCM-Quellen
Grün bedeutet:  TCM-Quellen und Studien
Schwarz :            Studien
Rot:                       Studien Hauptwirkung

Zum Verständnis der Abkürzungen des Schaubildes siehe

Struktur – und Wandlungsmodell der chinesischen Medizin






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